Magnetoencephalography abnormalities in adult mild traumatic brain injury: A systematic review.
Magnetoencephalography abnormalities in adult mild traumatic brain injury: A systematic review.
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DOI：
10.1016/j.nicl.2021.102697
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Evangelou N
中科院分区：
文献类型：
--
作者：
Allen CM;Halsey L;Topcu G;Rier L;Gascoyne LE;Scadding JW;Furlong PL;Dunkley BT;das Nair R;Brookes MJ;Evangelou N
脑磁图对轻度外伤性脑损伤异常的检测灵敏度高于临床影像学。轻度外伤性脑损伤后脑磁图连通性改变广泛存在。机器学习技术在分析脑磁图数据时产生很高的分类准确性。目前临床上常规应用脑磁图诊断轻度外伤性脑损伤的证据不足，全球外伤性脑损伤发病率呈上升趋势，其中至少80%为轻度。这些轻微的损伤在常规临床影像学上是不可见的。特定成像生物标志物的潜在临床作用，无论是诊断、预后还是指导和监测个性化治疗和康复的进展，都推动了几种新的神经成像模式的探索。本系统综述检查了脑磁图（MEG）的证据，以提供轻度创伤性脑损伤（mTBI）的成像生物标志物。我们的综述在PROSPERO上前瞻性注册：CRD42019151387。我们检索了EMBASE、MEDLINE、试验注册、PsycINFO、Cochrane图书馆和会议摘要，确定了37篇描述mTBI中MEG变化的论文。由于meta分析是不可能的，基于报告结果的异质性，我们提供了一个叙述性的综合结果。两种最有希望的脑磁图生物标志物是静息状态下的低频功率过剩和所有频段的广泛连接变化。这些可能代表了具有诊断应用潜力的生物标志物，反映了时间敏感性变化，或者可能能够提供临床相关的预后信息。此外，MEG产生的丰富数据非常适合机器学习分析的新方法，目前正在积极探索。在没有计算机断层扫描或磁共振成像证明的结构异常的情况下，MEG揭示了几个有希望的生物标志物。本综述尚未发现足够的证据支持目前在mTBI中常规临床应用MEG。然而，验证MEG的潜力将有助于满足民用、体育和军事医学的迫切临床需求。
Magnetoencephalography has higher sensitivity than clinical imaging to detect abnormalities in mild traumatic brain injury Excess resting state low frequency power is consistently detected following mild traumatic brain injury. There are widespread magnetoencephalography connectivity changes following mild traumatic brain injury. Machine learning techniques generate high classification accuracy when analysing magnetoencephalography data. Currently there is not enough evidence for routine clinical use of magnetoencephalography in mild traumatic brain injury The global incidence of traumatic brain injuries is rising, with at least 80% being classified as mild. These mild injuries are not visible on routine clinical imaging. The potential clinical role of a specific imaging biomarker be it diagnostic, prognostic or directing and monitoring progress of personalised treatment and rehabilitation has driven the exploration of several new neuroimaging modalities. This systematic review examined the evidence for magnetoencephalography (MEG) to provide an imaging biomarker in mild traumatic brain injury (mTBI). Our review was prospectively registered on PROSPERO: CRD42019151387. We searched EMBASE, MEDLINE, trial registers, PsycINFO, Cochrane Library and conference abstracts and identified 37 papers describing MEG changes in mTBI eligible for inclusion. Since meta-analysis was not possible, based on the heterogeneity of reported outcomes, we provide a narrative synthesis of results. The two most promising MEG biomarkers are excess resting state low frequency power, and widespread connectivity changes in all frequency bands. These may represent biomarkers with potential for diagnostic application, which reflect time sensitive changes, or may be capable of offering clinically relevant prognostic information. In addition, the rich data that MEG produces are well-suited to new methods of machine learning analysis, which is now being actively explored. MEG reveals several promising biomarkers, in the absence of structural abnormalities demonstrable with either computerised tomography or magnetic resonance imaging. This review has not identified sufficient evidence to support routine clinical use of MEG in mTBI currently. However, verifying MEG’s potential would help meet an urgent clinical need within civilian, sports and military medicine.
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影响因子：
5.7
作者：
Brookes MJ;Tewarie PK;Hunt BAE;Robson SE;Gascoyne LE;Liddle EB;Liddle PF;Morris PG
通讯作者：
Morris PG
DOI：
10.1016/j.nicl.2015.09.011
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
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作者：
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
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影响因子：
3
作者：
Antonakakis, Marios;Dimitriadis, Stavros I.;Papanicolaou, Andrew C.
通讯作者：
Papanicolaou, Andrew C.
影响因子：
4.7
作者：
Alamian G;Hincapié AS;Combrisson E;Thiery T;Martel V;Althukov D;Jerbi K
通讯作者：
Jerbi K