Comparison of World Health Organization and National Diabetes Data Group Procedures to Detect Abnormalities of Glucose Tolerance During Pregnancy
Comparison of World Health Organization and National Diabetes Data Group Procedures to Detect Abnormalities of Glucose Tolerance During Pregnancy
复制标题
世界卫生组织和国家糖尿病数据组检测妊娠期葡萄糖耐量异常程序的比较
作者：
D. Pettitt;P. Bennett;R. Hanson;K. Narayan;W. Knowler
目的 比较世界卫生组织 (WHO) 提出的一步程序与国家糖尿病数据组 (NDDG) 提出的两步程序，用于识别妊娠期糖耐量异常。研究设计和方法 对 127 名非糖尿病皮马印第安女性进行了 75 克 2 小时葡萄糖耐量测试（世界卫生组织标准）。 1 小时葡萄糖浓度升高（≥ 7.8 mmol/l）的患者被转介进行 100 g 3 小时葡萄糖耐量测试（国家糖尿病数据组标准）。通过比较巨大儿和剖腹产作为妊娠结局的频率来确定这两种测试程序的有效性。结果 42 名 1 小时血浆葡萄糖浓度≥ 7.8 mmol/l 的女性中，13 名未进行 100 g 测试，27 名测试正常，2 名测试异常。两步 100 克测试异常的两名女性 (100%) 一步 75 克测试也异常，但一步测试异常的 11 名女性 (18%) 中只有 2 人两步测试异常。 127 名妇女中有 16 名生下的婴儿体重≥ 4,000 克。其中六名女性 (38%) 使用一步测试被正确识别为异常，一名 (6%) 使用两步测试被正确识别为异常。在 7 名剖腹产妇女中，有 4 名 (57%) 的一步测试结果异常，但没有人的两步测试结果异常。结论 与更繁琐的两步 NDDG 测试相比，一步式 WHO 妊娠期糖耐量测试在出现不良后果的女性中出现异常的比例更高。一步测试的另一个优点是可以直接与非孕妇使用的标准葡萄糖耐量测试进行比较。
OBJECTIVE To compare the one-step procedure proposed by the World Health Organization (WHO) with the two-step procedure proposed by the National Diabetes Data Group (NDDG) for the identification of abnormalities of glucose tolerance during pregnancy. RESEARCH DESIGN AND METHODS One hundred twenty-seven non-diabetic Pima Indian women had a 75-g 2-h glucose tolerance test (WHO criteria). Those with an elevated 1-h glucose concentration (≥ 7.8 mmol/l) were referred for a 100-g 3-h glucose tolerance test (National Diabetes Data Group criteria). The effectiveness of the two test procedures was determined by comparing the frequency of macrosomia and cesarean section as outcomes of pregnancy. RESULTS Of 42 women with 1-h plasma glucose concentrations ≥ 7.8 mmol/l, 13 had no 100-g test, 27 had a normal test, and 2 had an abnormal test. Both women (100%) with abnormal two-step 100-g tests also had abnormal one-step 75-g tests, but only 2 of the 11 women (18%) with an abnormal one-step test had an abnormal two-step test. Sixteen of the 127 women delivered babies weighing ≥ 4,000 g. Six of these women (38%) were correctly identified as abnormal using the one-step test and one (6%) using the two-step test. Of seven women delivering by cesarean section, four (57%) had abnormal one-step tests, but none had an abnormal two-step test. CONCLUSIONS The one-step WHO test for glucose tolerance during pregnancy was abnormal in a greater percentage of women with adverse outcomes than the more cumbersome two-step NDDG test. The one-step test has the added advantage of being directly comparable to the standard glucose tolerance test used in nonpregnant women.
影响因子：
158.5
作者：
PETTITT, DJ;BAIRD, HR;KNOWLER, WC
通讯作者：
KNOWLER, WC