Advances in research on the regulatory mechanism of NHE1 in tumors.
Advances in research on the regulatory mechanism of NHE1 in tumors.
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NHE1在肿瘤中的调控机制研究进展
DOI：
10.3892/ol.2021.12534
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发表时间：
2021-04
期刊：
影响因子：
2.9
通讯作者：
Xie R
中科院分区：
文献类型：
--
作者：
Hu Y;Lou J;Jin Z;Yang X;Shan W;Du Q;Liao Q;Xu J;Xie R
肿瘤对人类健康构成重大威胁，存在着现代医学尚未克服的困难。研究表明，肿瘤微环境的酸碱平衡与人体的动态平衡密切相关，它调节着细胞增殖和分化、细胞内酶活性、细胞骨架组装和解聚等过程。已经确定细胞内和细胞外pH的调节依赖于一系列功能性离子转运体和氢离子通道，如Na+/H+交换蛋白（NHE）和三个Cl/HCO3-交换蛋白，其中NHE家族成员NHE1近年来越来越受到关注，特别是在pH调节与肿瘤相关性的研究中。NHE1是一种管家基因，编码一种在所有质膜表面广泛表达的蛋白质。由于NHE1的功能域决定了其n端和c端pHi，因此NHE1参与细胞pH微环境的调节。文献报道NHE1可以调节细胞体积，参与细胞内外离子的跨膜转运，影响细胞增殖和凋亡，调节细胞行为和细胞周期进程；然而，关于NHE1在各种系统的肿瘤发生和肿瘤发展中的作用的研究尚处于早期阶段。本文旨在综述NHE家族蛋白与各种系统性肿瘤的相关研究进展，以期为以pH微环境为靶点的抗肿瘤药物开发指明新的方向。
Tumors pose a major threat to human health and present with difficulties that modern medicine has yet to overcome. It has been demonstrated that the acid-base balance of the tumor microenvironment is closely associated with the dynamic balance in the human body and that it regulates several processes, such as cell proliferation and differentiation, intracellular enzyme activity, and cytoskeletal assembly and depolymerization. It has been well established that the regulation of intra- and extracellular pH depends on a series of functional ion transporters and hydrogen ion channels, such as the Na+/H+ exchanger (NHE) protein and thee Cl/HCO3- exchange protein, among which the NHE1 member of the NHE family has been attracting increasing attention in recent years, particularly in studies on the correlation between pH regulation and tumors. NHE1 is a housekeeping gene encoding a protein that is widely expressed on the surface of all plasma membranes. Due to its functional domain, which determines the pHi at its N-terminus and C-terminus, NHE1 is involved in the regulation of the cellular pH microenvironment. It has been reported in the literature that NHE1 can regulate cell volume, participate in the transmembrane transport of intracellular and extracellular ions, affect cell proliferation and apoptosis, and regulate cell behavior and cell cycle progression; however, research on the role of NHE1 in tumorigenesis and tumor development in various systems is at its early stages. The aim of the present study was to review the current research on the correlation between the NHE family proteins and various systemic tumors, in order to indicate a new direction for antitumor drug development with the pH microenvironment as the target.
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影响因子：
7.3
作者：
Gonzalez DM;Medici D
通讯作者：
Medici D
影响因子：
4.1
作者：
Cong D;Zhu W;Kuo JS;Hu S;Sun D
通讯作者：
Sun D
DOI：
10.1152/ajpgi.1996.271.3.g483
发表时间：
1996-09-01
影响因子：
4.5
作者：
Dudeja, PK;Rao, DD;Ramaswamy, K
通讯作者：
Ramaswamy, K
影响因子：
4.6
作者：
Hardonnière K;Saunier E;Lemarié A;Fernier M;Gallais I;Héliès-Toussaint C;Mograbi B;Antonio S;Bénit P;Rustin P;Janin M;Habarou F;Ottolenghi C;Lavault MT;Benelli C;Sergent O;Huc L;Bortoli S;Lagadic-Gossmann D
通讯作者：
Lagadic-Gossmann D
影响因子：
3.6
作者：
Ismail N;Giribabu N;Muniandy S;Salleh N
通讯作者：
Salleh N