TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.
TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.
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DOI：
10.7150/ijms.6749
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发表时间：
2013
影响因子：
3.6
通讯作者：
Hirai M
中科院分区：
文献类型：
--
作者：
Omatsu H;Kuwahara A;Yamamori M;Fujita M;Okuno T;Miki I;Tamura T;Nishiguchi K;Okamura N;Nakamura T;Azuma T;Hirano T;Ozawa K;Hirai M
背景资料：肿瘤坏死因子α（TNF-α）及其表面受体TNFRSF 1A和TNFRSF 1B的基因型已在各种癌症的进展、转移、临床疗效和预后方面进行了研究;然而，关于它们对食管鳞状细胞癌（ESCC）患者临床结局的影响知之甚少。在这项研究中，在46例接受确定性5-氟尿嘧啶（5-FU）/顺铂（CDDP）为基础的放化疗（CRT）治疗的日本男性ESCC患者中，回顾性评价了TNF-α和TNFRSF 1A基因型对预测临床应答、长期生存和严重急性毒性的作用。研究方法：第1-5、8-12天5-FU 400 mg/m2/d连续输注，第1 ~ 8天CDDP 40 mg/m2/d输注，第1-5、8-12、15-19天放疗2戈伊/d，间隔2周后重复第2个疗程。评估TNF-α-1031 T>C（rs 1799964）、-863 C>A（rs 1800630）、-857 C>T（rs 1799724）、-308 G>A（rs 1800629）、-238 G>A（rs361525）、TNFRSF 1A-609 G>T（rs 4149570）和36 A>G（rs767455）基因型。结果：发现TNF-α-857 C>T基因型可预测临床反应，即，完全缓解与否（P = 0.010，Fisher精确检验），但对长期生存无影响（CC-857 vs. CT-857 + TT-857，P = 0.072，Fisher精确检验，P = 0.070，对数秩检验）。结论：TNF-α-857 C>T基因型可预测接受确定性5-FU/CDDP为基础的CRT的日本ESCC患者的临床反应，更可能预测其长期生存。进一步的临床研究，更大数量的患者或体外实验，应进行评估的预测价值，该基因型后CRT。
Background: Genotypes of tumor necrosis factor alpha (TNF-α) and its surface receptors, TNFRSF1A and TNFRSF1B, have been examined in terms of the progression, metastasis, clinical efficacy, and prognosis of various cancers; however, little is known about their effects on clinical outcome in patients with esophageal squamous cell carcinoma (ESCC). In this study, TNF-α and TNFRSF1A genotypes were retrospectively evaluated in terms of predicting clinical response, long-term survival, and severe acute toxicities in 46 male Japanese ESCC patients treated with definitive 5-fluorouracil (5-FU)/cisplatin (CDDP)-based chemoradiotherapy (CRT). Methods: A course consisted of the continuous infusion of 5-FU at 400 mg/m2/day for days 1-5 and 8-12, the infusion of CDDP at 40 mg/m2/day on days 1 and 8, and radiation at 2 Gy/day on days 1-5, 8-12, and 15-19, with a second course being repeated after a 2-week interval. The TNF-α -1031T>C (rs1799964), -863C>A (rs1800630), -857C>T (rs1799724), -308G>A (rs1800629), -238G>A (rs361525), TNFRSF1A -609G>T (rs4149570), and 36A>G (rs767455) genotypes were evaluated. Results: The TNF-α -857C>T genotype was found to be predictive of clinical response, i.e., complete response or not (P = 0.010, Fisher's exact test), but had no effect on long-term survival (CC-857 vs. CT-857 + TT-857, P = 0.072, Fisher's exact test, P = 0.070, Log-rank test). Conclusions: The TNF-α -857C>T genotype was found to be predictive of clinical response and was more likely to predict long-term survival in Japanese ESCC patients receiving definitive 5-FU/CDDP-based CRT. Further clinical investigations with a larger number of patients or experiments in vitro should be performed to assess the predictive value of this genotype following CRT.
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影响因子：
3.6
作者：
Miki I;Nakamura T;Kuwahara A;Yamamori M;Nishiguchi K;Tamura T;Okuno T;Omatsu H;Mizuno S;Hirai M;Azuma T;Sakaeda T
通讯作者：
Sakaeda T
影响因子：
--
作者：
Higuchi, T;Seki, N;Itoh, K
通讯作者：
Itoh, K
影响因子：
4.2
作者：
Hatata, Tomoko;Higaki, Katsumi;Ikeguchi, Masahide
通讯作者：
Ikeguchi, Masahide
影响因子：
6.4
作者：
Matsuyama, Ryusei;Togo, Shinji;Shimada, Hiroshi
通讯作者：
Shimada, Hiroshi
影响因子：
3.7
作者：
Lv, K.;Chen, R.;Sun, S.
通讯作者：
Sun, S.