Oral symptoms and functional outcome related to oral and oropharyngeal cancer.
Oral symptoms and functional outcome related to oral and oropharyngeal cancer.
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DOI：
10.1007/s00520-010-0952-4
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发表时间：
2011-09
影响因子：
3.1
通讯作者：
Roodenburg, Jan L. N.
中科院分区：
文献类型：
--
作者：
Kamstra, Jolanda I.;Jager-Wittenaar, Harriet;Dijkstra, Pieter U.;Huisman, Paulien M.;van Oort, Rob P.;van der Laan, Bernard F. A. M.;Roodenburg, Jan L. N.
关键词：
本研究旨在评估：(1)口腔癌或口咽癌患者的口腔症状；(2)患者如何对口腔症状负担进行排序；(3)肿瘤、治疗和口腔症状对功能预后的影响。89例接受口腔或口咽癌治疗的患者被问及与开口、牙齿状况、口腔感觉功能、舌头活动、唾液功能和疼痛相关的口腔症状。他们被要求根据所经历的负担程度对这些口腔症状进行排序。下颌功能损害问卷（MFIQ）用于评估功能结局。在多元线性回归分析中，以MFIQ评分作为预测因子，输入与MFIQ评分相关的变量（p≤0.10）。唾液缺乏（52%）、张嘴受限（48%）和舌头活动受限（46%）是最常见的口腔症状。唾液缺乏是最常见的（32%），被列为最严重的口腔症状。对于接受放射治疗的患者，不能佩戴义齿、T3或T4期以及较高的年龄是MFIQ评分的预测因素。对于未接受放射治疗的患者，张嘴受限、不能佩戴义齿、舌头活动受限和下颌骨手术是MFIQ评分的预测因素。唾液缺乏不仅是口腔癌或口咽癌治疗后最常见的口腔症状，也是最繁重的口腔症状。在放射和未放射的患者中，不能佩戴义齿对功能预后有很大影响。
This study aimed to assess: (1) oral symptoms of patients treated for oral or oropharyngeal cancer; (2) how patients rank the burden of oral symptoms; (3) the impact of the tumor, the treatment, and oral symptoms on functional outcome. Eighty-nine patients treated for oral or oropharyngeal cancer were asked about their oral symptoms related to mouth opening, dental status, oral sensory function, tongue mobility, salivary function, and pain. They were asked to rank these oral symptoms according to the degree of burden experienced. The Mandibular Function Impairment Questionnaire (MFIQ) was used to assess functional outcome. In a multivariate linear regression analyses, variables related to MFIQ scores (p ≤ 0.10) were entered as predictors with MFIQ score as the outcome. Lack of saliva (52%), restricted mouth opening (48%), and restricted tongue mobility (46%) were the most frequently reported oral symptoms. Lack of saliva was most frequently (32%) ranked as the most burdensome oral symptom. For radiated patients, an inability to wear a dental prosthesis, a T3 or T4 stage, and a higher age were predictive of MFIQ scores. For non-radiated patients, a restricted mouth opening, an inability to wear a dental prosthesis, restricted tongue mobility, and surgery of the mandible were predictive of MFIQ scores. Lack of saliva was not only the most frequently reported oral symptom after treatment for oral or oropharyngeal cancer, but also the most burdensome. Functional outcome is strongly influenced by an inability to wear a dental prosthesis in both radiated and non-radiated patients.
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影响因子：
4.8
作者：
Dijkstra, P. U.;Sterken, M. W.;Roodenburg, J. L. N.
通讯作者：
Roodenburg, J. L. N.
影响因子：
1.9
作者：
Fricton, JR;Look, JO;Swift, J
通讯作者：
Swift, J
DOI：
10.1016/0266-4356(92)90130-b
发表时间：
1992-02-01
影响因子：
1.8
作者：
FINLAY, PM;DAWSON, F;SOUTAR, DS
通讯作者：
SOUTAR, DS
影响因子：
3.1
作者：
Dirix, Piet;Nuyts, Sandra;Van den Bogaert, Walter
通讯作者：
Van den Bogaert, Walter
影响因子：
3.4
作者：
LOGEMANN, JA;RADEMAKER, AW;KAHRILAS, PJ
通讯作者：
KAHRILAS, PJ