Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.
Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.
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DOI:
10.1007/s00239-016-9753-9
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发表时间:
2016-08
影响因子:
3.9
通讯作者:
Aquadro, Charles F.
中科院分区:
文献类型:
--
作者:
Choi, Jae Young;Aquadro, Charles F.
In Drosophila, many studies have examined the short or long term evolution occurring across synonymous sites. Few, however, have examined both the recent and long-term evolution to gain a complete view of this selection. Here we have analyzed Drosophila ananassae DNA polymorphism and divergence data using several different methods, and have identified evidence of positive selection favoring preferred codons in both recent and long-term evolutionary time scale. Further in D. ananassae, the strength of selection for preferred codons was stronger on the X chromosome compared to the autosomes. We show that this stronger selection is not due to higher gene expression of X linked genes. Analysis of the selectively neutral introns indicated the X chromosome also had a preference for GC over AT nucleotides, potentially from GC biased gene conversions (gcBGC) that can also affect the base composition of synonymous sites. Thus selection for preferred codons and gcBGC both seem to be partially responsible for shaping the D. ananassae synonymous site evolution.
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DOI:
10.1073/pnas.96.8.4482
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1999-04-13
影响因子:
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