Intravesical treatments of bladder cancer: review.
Intravesical treatments of bladder cancer: review.
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DOI：
10.1007/s11095-008-9566-7
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发表时间：
2008-07
影响因子：
3.7
通讯作者：
Au, Jessie L. -S.
中科院分区：
文献类型：
--
作者：
Shen, Zancong;Shen, Tong;Wientjes, M. Guillaume;O'Donnell, Michael A.;Au, Jessie L. -S.
关键词：
对于膀胱癌，膀胱内化疗/免疫治疗被广泛用作手术经尿道切除术后的辅助治疗，而全身治疗通常保留用于更高阶段、肌肉侵入或转移性疾病。膀胱内治疗的目标是通过直接细胞消融或免疫刺激根除现有或残留的肿瘤。膀胱的独特性质使其成为评估区域治疗的其他新实验方法的肥沃土壤，包括离子电渗/电泳、局部热疗、渗透增强剂、生物粘附载体、磁靶向颗粒和基因治疗的共同给药。此外，由于其独特的解剖学性质，膀胱内治疗期间和之后膀胱组织各层中的药物浓度-时间曲线可以通过由药物处置和转运动力学参数组成的数学模型来描述。药物递送数据又可以与有效药物暴露相结合，以推断治疗功效，从而帮助选择最佳方案。据我们所知，膀胱癌的膀胱内治疗是第一个使用计算药理学方法设计并成功预测随机III期试验（使用丝裂霉素C）结果的例子。本文综述了膀胱灌注治疗的药理学原理和现状，以及计算在优化药物靶点和治疗效果方面的应用。
For bladder cancer, intravesical chemo/immunotherapy is widely used as adjuvant therapies after surgical transurethal resection, while systemic therapy is typically reserved for higher stage, muscle-invading, or metastatic diseases. The goal of intravesical therapy is to eradicate existing or residual tumors through direct cytoablation or immunostimulation. The unique properties of the urinary bladder render it a fertile ground for evaluating additional novel experimental approaches to regional therapy, including iontophoresis/electrophoresis, local hyperthermia, co-administration of permeation enhancers, bioadhesive carriers, magnetic-targeted particles and gene therapy. Furthermore, due to its unique anatomical properties, the drug concentration-time profiles in various layers of bladder tissues during and after intravesical therapy can be described by mathematical models comprised of drug disposition and transport kinetic parameters. The drug delivery data, in turn, can be combined with the effective drug exposure to infer treatment efficacy and thereby assists the selection of optimal regimens. To our knowledge, intravesical therapy of bladder cancer represents the first example where computational pharmacological approach was used to design, and successfully predicted the outcome of, a randomized phase III trial (using mitomycin C). This review summarizes the pharmacological principles and the current status of intravesical therapy, and the application of computation to optimize the drug delivery to target sites and the treatment efficacy.
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影响因子：
6.6
作者：
CHAI, M;WIENTJES, MG;AU, JLS
通讯作者：
AU, JLS
影响因子：
19.7
作者：
CORRY, PM;ROBINSON, S;GETZ, S
通讯作者：
GETZ, S
影响因子：
51.1
作者：
Di Stasi, SM;Giannantoni, A;Stephen, RL
通讯作者：
Stephen, RL
影响因子：
2.4
作者：
Clinton, SK;Canto, E;O'Donnell, MA
通讯作者：
O'Donnell, MA
影响因子：
168.9
作者：
Alton, EWFW;Stern, M;Geddes, DM
通讯作者：
Geddes, DM