Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors.
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DOI：
10.3389/fonc.2017.00216
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发表时间：
2017
影响因子：
4.7
通讯作者：
Hursting SD
中科院分区：
文献类型：
--
作者：
Doerstling SS;O'Flanagan CH;Hursting SD
肥胖与许多类型癌症的风险增加和预后不良有关。参与全身代谢的几种与肥胖相关的宿主因素可以影响肿瘤的发生、进展和/或对治疗的反应，这些因素被认为是肥胖对癌症发病率和结局的复杂影响的关键因素。这样的宿主因子包括全身代谢调节剂，包括胰岛素、胰岛素样生长因子1、脂肪因子、炎症相关分子和类固醇激素，以及肿瘤微环境的细胞和结构组分，特别是脂肪组织。这些分泌的和结构性宿主因子对于癌细胞的内在代谢特征是外在的，并且与癌细胞的内在代谢特征相互作用以影响其生长和扩散。本文将重点介绍这些肿瘤细胞的内在和外在因素的相互作用的背景下，能量平衡，确定新的干预目标，以预防肥胖相关的癌症。
Obesity is associated with increased risk and poor prognosis of many types of cancers. Several obesity-related host factors involved in systemic metabolism can influence tumor initiation, progression, and/or response to therapy, and these have been implicated as key contributors to the complex effects of obesity on cancer incidence and outcomes. Such host factors include systemic metabolic regulators including insulin, insulin-like growth factor 1, adipokines, inflammation-related molecules, and steroid hormones, as well as the cellular and structural components of the tumor microenvironment, particularly adipose tissue. These secreted and structural host factors are extrinsic to, and interact with, the intrinsic metabolic characteristics of cancer cells to influence their growth and spread. This review will focus on the interplay of these tumor cell–intrinsic and extrinsic factors in the context of energy balance, with the objective of identifying new intervention targets for preventing obesity-associated cancer.
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影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
DOI：
10.1080/15384101.2015.1041684
发表时间：
2015
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Fazolini NP;Cruz AL;Werneck MB;Viola JP;Maya-Monteiro CM;Bozza PT
通讯作者：
Bozza PT
影响因子：
--
作者：
Balaban S;Lee LS;Schreuder M;Hoy AJ
通讯作者：
Hoy AJ
影响因子：
11.4
作者：
Bouchard, C;Marquardt, J;Eilers, M
通讯作者：
Eilers, M
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B