In-stent thin-cap fibroatheroma after drug-eluting stent implantation: ex-vivo evaluation of optical coherence tomography and intracoronary angioscopy.
In-stent thin-cap fibroatheroma after drug-eluting stent implantation: ex-vivo evaluation of optical coherence tomography and intracoronary angioscopy.
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药物洗脱支架植入后支架内薄帽纤维粥样硬化：光学相干断层扫描和冠状动脉内血管镜检查的离体评估。
DOI：
10.1016/j.jcin.2013.07.018
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
T. Masuyama
中科院分区：
文献类型：
--
作者：
K. Fujii;H. Hao;T. Imanaka;T. Kawano;T. Takayama;A. Hirayama;Tsutomu Yamada;H. Ishibashi;S. Hirota;T. Masuyama
根据最近的病理学研究，支架植入后新生内膜内TCFA样病变的破裂已被长期报道，并被认为是导致极晚期支架血栓形成的原因[1]。据我们所知，这是第一例OCT和CAS药物洗脱支架置入后体外询问含有新生内膜的支架内TCFA的尸检标本。在OCT图像上，由于脂类在1,000 nm附近的强光吸收和散射，富含脂质的坏死核显示为低信号团块(2)。因此，如果新生内膜内有富含脂质的坏死核，则OCT不能显示支架支柱。另一方面，由于OCT信号不会被这种材料衰减，因此可以看到组织化纤维蛋白血栓后面的支架支柱(3)。因此，重要的是要确定支架内TCFA样新生内膜是“可见”还是“不可见”的低信号区域后面的支架支柱。
DiscussionBased on recent pathological study, rupture of a TCFA-like lesion within the neointima has been reported in the long term after stent implantation and has been proposed to be responsible for very late stent thrombosis (1). To the best of our knowledge, this is the first case of ex-vivo interrogation of in-stent TCFA containing neointima after drug-eluting stent implantation with OCT and CAS by autopsy specimen. On OCT images, the lipid-rich necrotic core appears as a low-signal-intensity mass because of the strong optical absorption and scattering of lipids at light wavelengths around 1,000 nm (2). Therefore, stent struts cannot be visualized by OCT if there is a lipid-rich necrotic core within the neointima. On the other hand, stent struts behind organized fibrin thrombus can be visualized because OCT signals are not attenuated by this material (3). Therefore, it is important to identify the in-stent TCFA-like neointima whether stent struts behind a low-signal-intensity area are “visible” or “invisible.”
影响因子：
24
作者：
Nakazawa, Gaku;Otsuka, Fumiyuki;Nakano, Masataka;Vorpahl, Marc;Yazdani, Saami K.;Ladich, Elena;Kolodgie, Frank D.;Finn, Aloke V.;Virmani, Renu
通讯作者：
Virmani, Renu
影响因子：
3.5
作者：
Allen, Thomas J.;Hall, Andrew;Beard, Paul C.
通讯作者：
Beard, Paul C.