Development of a high resolution MRI intracranial atherosclerosis imaging phantom.
Development of a high resolution MRI intracranial atherosclerosis imaging phantom.
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DOI：
10.1136/neurintsurg-2016-012974
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发表时间：
2018-03
影响因子：
4.8
通讯作者：
Turan TN
中科院分区：
文献类型：
--
作者：
Chueh JY;van der Marel K;Gounis MJ;LeMatty T;Brown TR;Ansari SA;Carroll TJ;Buck AK;Zhou XJ;Chatterjee AR;King RM;Mao H;Zheng S;Brooks OW;Rappleye JW;Swartz RH;Feldmann E;Turan TN
目前，既没有颅内动脉粥样硬化疾病（ICAD）血管壁MR成像的标准方案，也没有比较MR序列的金标准体模。在这项研究中，斑块幻影的发展和特点，提供了一个平台，建立一个统一的成像方法ICAD。3D打印患者特定的注射模具以构建几何精确的ICAD体模。将聚乙烯醇水凝胶注入核壳模型中形成狭窄动脉。ICAD体模包含模拟狭窄血管和斑块成分（包括纤维帽和脂质核心）的材料。在18个月的时间内，使用高分辨率锥形束CT扫描两个体模，并与8个不同部位的4个不同3 T MRI系统进行比较。通过管腔尺寸和对比度噪声比（CNR）评估体模间变异性。狭窄处最小管腔半径的定量评价显示，模型1中的半径平均为0.80 mm（95% CI：[0.77，0.82]mm），模型2中的半径平均为0.77 mm（95% CI：[0.74，0.81]mm）。在脂质和血管壁之间的比较中观察到最高CNR。为了评价生产重现性，两种型号之间的CNR变异性的平均绝对差为4.31（95% CI：[3.82，5.78]）。同一扫描仪相隔7个月的图像之间的CNR变化为2.5-6.2，显示了可再现的体模耐久性。成功构建了由狭窄血管壁和斑块成分组成的斑块体模，用于多中心高分辨率MRI标准化。
Currently, there is neither a standard protocol for vessel wall MR-imaging of intracranial atherosclerotic disease (ICAD), nor a gold standard phantom to compare MR-sequences. In this study, a plaque phantom is developed and characterized that provides a platform for establishing a uniform imaging approach for ICAD. A patient-specific injection mold was 3D-printed to construct a geometrically accurate ICAD phantom. Polyvinyl alcohol hydrogel was infused into the core-shell mold to form the stenotic artery. The ICAD phantom incorporated materials mimicking a stenotic vessel and plaque components including fibrous cap and lipid core. Two phantoms were scanned using high-resolution cone-beam CT and compared to four different 3T MRI systems across 8 different sites over the period of 18 months. Inter-phantom variability was assessed by lumen dimensions and contrast-to-noise ratio (CNR). Quantitative evaluation of the minimum lumen radius in the stenosis showed that the radius was on average 0.80mm (95% CI: [0.77, 0.82]mm) in model 1 and 0.77mm (95% CI: [0.74, 0.81]mm) in model 2. The highest CNRs were observed for comparisons between lipid and vessel wall. To evaluate the manufacturing reproducibility, the CNR variability between the two models had an average absolute difference of 4.31 (95% CI: [3.82, 5.78]). Variation in CNR between the images from the same scanner separated by 7 months was 2.5–6.2, showing reproducible phantom durability. A plaque phantom composed of a stenotic vessel wall and plaque components was successfully constructed for multi-center high-resolution MRI standardization.
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影响因子：
3.5
作者：
Vakil, P.;Vranic, J.;Ansari, S. A.
通讯作者：
Ansari, S. A.
影响因子：
5.7
作者：
Woods, RP
通讯作者：
Woods, RP
动脉粥样硬化大脑中动脉的3T高分辨率MRI形态特征
影响因子：
3.5
作者：
Zhu, X. J.;Du, B.;Jiang, W. -J.
通讯作者：
Jiang, W. -J.
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC
影响因子：
5.7
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group