Unbiased average age-appropriate atlases for pediatric studies.
Unbiased average age-appropriate atlases for pediatric studies.
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DOI：
10.1016/j.neuroimage.2010.07.033
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发表时间：
2011-01-01
期刊：
影响因子：
5.7
通讯作者：
Brain Development Cooperative Group
中科院分区：
文献类型：
--
作者：
Fonov V;Evans AC;Botteron K;Almli CR;McKinstry RC;Collins DL;Brain Development Cooperative Group
用于磁共振成像（MRI）的空间归一化、配准和分割技术通常使用目标或模板体积来促进处理，利用先验信息，并定义用于分析的公共坐标系。在神经影像学文献中，MNI 305 TalaIrach坐标系通常用作标准模板。然而，在研究儿童人群时，成人大脑的变化使MNI 305在处理儿童大脑图像时不是最佳的。在开发过程中发生的形态学变化使得使用适合年龄的模板是可取的，以减少潜在的错误，并最大限度地减少儿科数据处理过程中的偏倚。本文介绍了用于为儿科研究创建无偏倚、年龄适合的MRI图谱模板的方法，这些模板代表了4.5-18.5岁年龄范围的平均解剖结构，同时保持了高水平的解剖细节和对比度。为特定发育重要年龄范围创建解剖学T1加权、T2加权和质子密度加权模板，使用来自美国人口最大流行病学代表性（健康和正常）样本的数据，其中每个受试者都经过仔细筛选以确定医疗和精神因素，并使用已建立的神经心理学和行为评估进行表征。.通过计算每个特定年龄范围的灰质、白色物质和脑脊液的平均组织图，并通过使用66名年轻（4.5-6.9岁）参与者进行基于体素变形的形态测量学研究，以证明使用年龄适当的模板的益处，对这些年龄特异性模板的使用进行了评价。这些地图集/模板的公开可用性将促进儿科MRI数据的分析，并能够在儿科研究专用的通用标准化空间中比较研究之间的结果。
Spatial normalization, registration, and segmentation techniques for Magnetic Resonance Imaging (MRI) often use a target or template volume to facilitate processing, take advantage of prior information, and define a common coordinate system for analysis. In the neuroimaging literature, the MNI305 Talairach-like coordinate system is often used as a standard template. However, when studying pediatric populations, variation from the adult brain makes the MNI305 suboptimal for processing brain images of children. Morphological changes occurring during development render the use of age-appropriate templates desirable to reduce potential errors and minimize bias during processing of pediatric data. This paper presents the methods used to create unbiased, age-appropriate MRI atlas templates for pediatric studies that represent the average anatomy for the age range of 4.5–18.5 years, while maintaining a high level of anatomical detail and contrast. The creation of anatomical T1-weighted, T2-weighted, and proton density-weighted templates for specific developmentally important age-ranges, used data derived from the largest epidemiological, representative (healthy and normal) sample of the U.S. population, where each subject was carefully screened for medical and psychiatric factors and characterized using established neuropsychological and behavioral assessments. . Use of these age-specific templates was evaluated by computing average tissue maps for gray matter, white matter, and cerebrospinal fluid for each specific age range, and by conducting an exemplar voxel-wise deformation-based morphometry study using 66 young (4.5–6.9 years) participants to demonstrate the benefits of using the age-appropriate templates. The public availability of these atlases/templates will facilitate analysis of pediatric MRI data and enable comparison of results between studies in a common standardized space specific to pediatric research.
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影响因子：
1.3
作者：
COLLINS, DL;NEELIN, P;EVANS, AC
通讯作者：
EVANS, AC
影响因子：
4.8
作者：
Collins, DL;Holmes, CJ;Evans, AC
通讯作者：
Evans, AC
影响因子：
5.7
作者：
Blanton, RE;Levitt, JG;Toga, AW
通讯作者：
Toga, AW
影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
DOI：
10.1097/00004583-200109000-00009
发表时间：
2001-09-01
影响因子：
13.3
作者：
Durston, S;Pol, HEH;van Engeland, H
通讯作者：
van Engeland, H