Concordance in HPV Detection Between Self-Collected and Health Provider-Collected Cervicovaginal Samples Using careHPV in Tanzanian Women.
Concordance in HPV Detection Between Self-Collected and Health Provider-Collected Cervicovaginal Samples Using careHPV in Tanzanian Women.
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坦桑尼亚妇女使用careHPV自采和健康提供者采集的宫颈阴道样本之间HPV检测的一致性
DOI：
10.1200/go.20.00598
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发表时间：
2021-06
影响因子：
4.5
通讯作者：
Kjaer SK
中科院分区：
文献类型：
--
作者：
Katanga JJ;Rasch V;Manongi R;Pembe AB;Mwaiselage JD;Kjaer SK
子宫颈癌普查是预防高危妇女患上该疾病的策略之一。人乳头瘤病毒（HPV）DNA检测由于其高灵敏度而越来越多地用作宫颈癌筛查方法。自行采集宫颈标本有可能提高参与率。然而，关于使用careHPV方法检测高危HPV的自我收集和提供者收集样本之间的比较信息有限。该研究旨在比较careHPV在自我收集和提供者收集的宫颈样本中的HPV检测，并评估自我收集技术的可接受性。参加坦桑尼亚海洋路癌症研究所、基利曼哈罗基督教医疗中心或马文齐医院宫颈癌筛查诊所的妇女也被纳入研究。他们接受了面对面的采访，HIV检测，并使用Evalyn Brush收集了自我样本。随后，他们由一名保健提供者采集了宫颈样本。使用careHPV检测两个样本的高危HPV DNA。共有464名女性参与了这项研究。医疗服务提供者样本中的高危HPV患病率为19.0%（95%CI，15.6至22.9），但自采样本中的患病率较低（13.8%; 95%CI，10.9至17.3）。两组样本之间的总体一致性为90.5%（95% CI，87.5 - 93.0），一致性为（κ = 0.66; 95% CI，0.56 - 0.75）。敏感性和特异性分别为61.4%（95%CI，50.4至71.6）和97.3%（95%CI，95.2至98.7），随年龄而变化。大多数妇女倾向于自己收集（79.8%）。总体而言，自我采样似乎是替代保健提供者采集的一种可靠办法，为大多数妇女所接受。然而，向妇女提供关于样本采集适当程序的指导很重要。
Cervical cancer screening is one of the strategies to prevent the disease among women at risk. Human papillomavirus (HPV) DNA testing is increasingly used as the cervical cancer screening method because of its high sensitivity. Self-collection of cervical specimens has the potential to improve participation. However, there is only limited information on comparison between self-collected and provider-collected samples with regard to detection of high-risk HPV using the careHPV method. The study aimed to compare HPV detection by careHPV in self-collected and provider-collected cervical samples and to assess the acceptability of self-collection techniques. Women attending cervical cancer screening clinics at Ocean Road Cancer Institute, Kilimanjaro Christian Medical Centre or Mawenzi Hospital in Tanzania were included in the study. They underwent a face-to-face interview, HIV testing, and collected a self-sample using Evalyn Brush. Subsequently, they had a cervical sample taken by a health provider. Both samples were tested for high-risk HPV DNA using careHPV. Overall, 464 women participated in the study. The high-risk HPV prevalence was 19.0% (95% CI, 15.6 to 22.9) in the health provider samples, but lower (13.8%; 95% CI, 10.9 to 17.3) in the self-collected samples. There was a good overall agreement 90.5% (95% CI, 87.5 to 93.0) and concordance (κ = 0.66; 95% CI, 0.56 to 0.75) between the two sets of samples. Sensitivity and specificity were 61.4% (95% CI, 50.4 to 71.6) and 97.3% (95% CI, 95.2 to 98.7), respectively, varying with age. Most women preferred self-collection (79.8%). Overall, self-sampling seems to be a reliable alternative to health-provider collection and is acceptable to the majority of women. However, instructions on proper procedures for sample collection to the women are important.
DOI：
10.31729/jnma.3857
发表时间：
2018-11
期刊：
JNMA; journal of the Nepal Medical Association
影响因子：
--
作者：
Thapa N;Maharjan M;Shrestha G;Maharjan N;Lindell D;Zuo N;Yang J;Maskey N;Cai H
通讯作者：
Cai H