Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.
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DOI：
10.1016/j.clinre.2018.03.009
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发表时间：
2018-09
影响因子：
2.7
通讯作者：
Glaser S
中科院分区：
文献类型：
--
作者：
Ehrlich L;Scrushy M;Meng F;Lairmore TC;Alpini G;Glaser S
肝纤维化的特征是细胞外基质(ECM)异常积聚，可导致乳管减少、肝硬变，甚至恶变。在这篇综述中，我们研究了以广泛的胆道纤维化为特征的胆汁淤积性肝病，如原发性硬化性胆管炎、原发性胆管炎、多囊肝病，以及MDR2−/−和bdl小鼠模型。胆管损伤后，胆管上皮细胞即胆管上皮细胞发生反应，并采用神经内分泌表型，以自分泌和旁分泌的方式分泌神经激素和神经肽并对其做出反应。新的证据表明，胆管细胞影响微环境中ECM和基质细胞的变化，并对此做出反应。例如，激活的肌成纤维细胞和肝星状细胞是胶原沉积和胆管纤维化的主要驱动因素。此外，肝脏富含肾上腺素能、胆碱能和肽能纤维，这些纤维可以释放神经激素和多肽来维持体内平衡，在疾病状态下可能会精神错乱。本文综述了胆管细胞如何与周围环境相互作用，尤其是自主神经和感觉调节如何影响纤维化的病理生理学。
Hepatic fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) that can lead to ductopenia, cirrhosis, and even malignant transformation. In this review, we examine cholestatic liver diseases characterized by extensive biliary fibrosis such as Primary Sclerosing Cholangitis (PSC), Primary Biliary Cholangitis (PBC), Polycystic Liver Disease (PLD), and MDR2−/− and BDL mouse models. Following biliary injury, cholangiocytes, the epithelial cells that line the bile ducts, become reactive and adopt a neuroendocrine phenotype in which they secrete and respond to neurohormones and neuropeptides in an autocrine and paracrine fashion. Emerging evidence indicates that cholangiocytes influence and respond to changes in the ECM and stromal cells in the microenvironment. For example, activated myofibroblasts and hepatic stellate cells are major drivers of collagen deposition and biliary fibrosis. Additionally, the liver is richly innervated with adrenergic, cholinergic, and peptidergic fibers that release neurohormones and peptides to maintain homeostasis and can be deranged in disease states. This review summarizes how cholangiocytes interact with their surrounding environment, with particular focus on how autonomic and sensory regulation affects fibrotic pathophysiology.
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DOI：
10.1038/labinvest.2009.6
发表时间：
2009-04
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
通讯作者：
--
影响因子：
29.4
作者：
Alpini, G;Roberts, S;LaRusso, NF
通讯作者：
LaRusso, NF
哺乳动物烟碱乙酰胆碱受体：从结构到功能。
影响因子：
33.6
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
通讯作者：
Rogers SW
影响因子：
25.7
作者：
Francis, H;Glaser, S;Alpini, G
通讯作者：
Alpini, G
影响因子：
29.4
作者：
Glaser S;Meng F;Han Y;Onori P;Chow BK;Francis H;Venter J;McDaniel K;Marzioni M;Invernizzi P;Ueno Y;Lai JM;Huang L;Standeford H;Alvaro D;Gaudio E;Franchitto A;Alpini G
通讯作者：
Alpini G