Quorum sensing and bacterial social interactions in biofilms.

Quorum sensing and bacterial social interactions in biofilms.
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DOI:
10.3390/s120302519
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发表时间:
2012
期刊:
Sensors (Basel, Switzerland)
影响因子:
--
通讯作者:
Tian X
Tian X
中科院分区:
其他
文献类型:
--
作者:
Li YH;Tian X

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众所周知,许多细菌通过一种称为群体感应(QS)的机制来调节它们的合作活动和生理过程,其中细菌细胞通过释放、感知和响应小的可扩散信号分子来相互通信。细菌像多细胞生物一样作为一个群体进行社会互动的交流和行为能力,为细菌在宿主定植、生物膜形成、防御竞争者和适应不断变化的环境方面提供了显着的好处。重要的是,许多 QS 控制的活动与细菌的毒力和致病潜力有关。因此,了解群体感应机制的分子细节及其受控的社会活动可能为控制细菌感染开辟一条新途径。
Many bacteria are known to regulate their cooperative activities and physiological processes through a mechanism called quorum sensing (QS), in which bacterial cells communicate with each other by releasing, sensing and responding to small diffusible signal molecules. The ability of bacteria to communicate and behave as a group for social interactions like a multi-cellular organism has provided significant benefits to bacteria in host colonization, formation of biofilms, defense against competitors, and adaptation to changing environments. Importantly, many QS-controlled activities have been involved in the virulence and pathogenic potential of bacteria. Therefore, understanding the molecular details of quorum sensing mechanisms and their controlled social activities may open a new avenue for controlling bacterial infections.
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