Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain.
Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain.
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DOI：
10.3390/molecules27030595
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发表时间：
2022-01-18
期刊：
影响因子：
--
通讯作者：
Che T
中科院分区：
文献类型：
--
作者：
El Daibani A;Che T
在我们今天的社会中，疼痛已经成为大多数人的主要压力来源。开发新的疼痛治疗方法，同时专注于减少其不良反应至关重要。在新的疼痛疗法的整个开发范围内，痛敏素/痛敏素FQ受体（NOP受体）似乎是一个令人鼓舞的焦点。集中于NOP受体来治疗慢性疼痛，具有有限范围的不希望的作用，作为原型阿片类吗啡的合适替代品，原型阿片类吗啡可能导致过量呼吸抑制引起的危及生命的作用，以及产生滥用和成瘾。除了这些有害影响外，阿片类药物的流行也是美国最具灾难性的公共卫生问题之一。本文就控制NOP受体细胞运输的分子和细胞结构以及支持NOP受体及其配体在疼痛治疗中作用的研究作一综述。
In our society today, pain has become a main source of strain on most individuals. It is crucial to develop novel treatments against pain while focusing on decreasing their adverse effects. Throughout the extent of development for new pain therapies, the nociceptin/orphanin FQ receptor (NOP receptor) has appeared to be an encouraging focal point. Concentrating on NOP receptor to treat chronic pain with limited range of unwanted effects serves as a suitable alternative to prototypical opioid morphine that could potentially lead to life-threatening effects caused by respiratory depression in overdose, as well as generate abuse and addiction. In addition to these harmful effects, the uprising opioid epidemic is responsible for becoming one of the most disastrous public health issues in the US. In this article, the contributing molecular and cellular structure in controlling the cellular trafficking of NOP receptor and studies that support the role of NOP receptor and its ligands in pain management are reviewed.
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