Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages.
Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages.
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DOI：
10.3389/fimmu.2018.02104
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发表时间：
2018
影响因子：
7.3
通讯作者：
Li MO
中科院分区：
文献类型：
--
作者：
Chou C;Li MO
淋巴细胞是免疫系统的重要组成部分。传统上认为，所有淋巴细胞都在次级淋巴器官之间循环，只有在激活后才会进入非淋巴组织。近年来，发现了一个不同的非循环淋巴细胞家族。这些细胞包括先天淋巴细胞、先天样T细胞和一部分常规T细胞。跨越先天适应性谱，这些组织驻留淋巴细胞执行特殊功能，并与其他免疫细胞类型相互作用，以维持组织在稳态和病理状态下的完整性和稳态。在这篇综述中，我们提供了异质组织驻留淋巴细胞群的概述，讨论了它们的发展，并强调了它们在微生物感染和癌症背景下的功能。
Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family of non-circulating lymphocytes have been identified. These include innate lymphocytes, innate-like T cells and a subset of conventional T cells. Spanning the innate-adaptive spectrum, these tissue-resident lymphocytes carry out specialized functions and cross-talk with other immune cell types to maintain tissue integrity and homeostasis both at the steady state and during pathological conditions. In this review, we provide an overview of the heterogeneous tissue-resident lymphocyte populations, discuss their development, and highlight their functions both in the context of microbial infection and cancer.
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影响因子：
7.3
作者：
Carrega P;Ferlazzo G
通讯作者：
Ferlazzo G
影响因子：
30.5
作者：
Cortez VS;Ulland TK;Cervantes-Barragan L;Bando JK;Robinette ML;Wang Q;White AJ;Gilfillan S;Cella M;Colonna M
通讯作者：
Colonna M
影响因子：
30.5
作者：
Crawford G;Hayes MD;Seoane RC;Ward S;Dalessandri T;Lai C;Healy E;Kipling D;Proby C;Moyes C;Green K;Best K;Haniffa M;Botto M;Dunn-Walters D;Strid J
通讯作者：
Strid J
影响因子：
64.5
作者：
Barros, Rafael Di Marco;Roberts, Natalie A.;Dart, Robin J.;Vantourout, Pierre;Jandke, Anett;Nussbaumer, Oliver;Deban, Livija;Cipolat, Sara;Hart, Rosie;Iannitto, Maria Luisa;Laing, Adam;Spencer-Dene, Bradley;East, Philip;Gibbons, Deena;Irving, Peter M.;Pereira, Pablo;Steinhoff, Ulrich;Hayday, Adrian
通讯作者：
Hayday, Adrian
影响因子：
64.5
作者：
Azizi E;Carr AJ;Plitas G;Cornish AE;Konopacki C;Prabhakaran S;Nainys J;Wu K;Kiseliovas V;Setty M;Choi K;Fromme RM;Dao P;McKenney PT;Wasti RC;Kadaveru K;Mazutis L;Rudensky AY;Pe'er D
通讯作者：
Pe'er D