Coaxial double-tubular compliant arterial graft prosthesis: time-dependent morphogenesis and compliance changes after implantation.
Coaxial double-tubular compliant arterial graft prosthesis: time-dependent morphogenesis and compliance changes after implantation.
复制标题
同轴双管顺应性动脉移植假体：植入后时间依赖性形态发生和顺应性变化。
DOI：
10.1002/jbm.a.10462
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Matsuda
中科院分区：
文献类型：
--
作者：
H. Sonoda;K. Takamizawa;Y. Nakayama;H. Yasui;T. Matsuda
为了减少天然动脉和人工移植物之间的顺应性不匹配，我们已经开发了一种同轴双管顺应性移植物，使用多微孔分段聚氨酯（SPU）薄膜，其模拟了天然动脉的管腔内压力和血管内径（P-D）之间的关系（称为“J”曲线）。通过将具有肝素固定化光固化明胶涂层的高顺应性内管插入具有光固化亲水性聚合物涂层的低顺应性外管中来同轴组装移植物。将28个同轴双管顺应性移植物以端对端的方式植入犬颈总动脉中长达12个月。总的通畅率为86%（24/28），未观察到破裂或囊肿形成。通过经吻合口和透壁组织向内生长形成新动脉壁，导致在管腔表面上和进入双管移植物的管间空间的新动脉组织形成，在早期阶段主要伴有肌成纤维细胞和炎性细胞，在植入的晚期阶段伴有内皮化和富含胶原的细胞外基质。通过亲水性聚合物涂层防止周围组织与外管粘连。虽然植入原型模型的J曲线在植入后1个月保持不变，但由于植入后3个月和6个月内管外表面与周围组织之间的组织长入和组织粘附，观察到J曲线受损。然而，在植入后12个月，由于SPU膜的生物降解，植入的同轴双管移植物表现出高顺应性。
In order to reduce the compliance mismatch between the native artery and the artificial graft, we have developed a coaxial double-tubular compliant graft, using multiply micropored segmented polyurethane (SPU) thin films, which mimics the relationship between the intraluminal pressure and vessel internal diameter (P-D) of the native artery (termed "J" curve). The graft was coaxially assembled by inserting a high-compliance inner tube with a heparin-immobilized photocured gelatin coating layer into a low-compliance outer tube with a photocured hydrophilic polymer coating layer. Twenty-eight coaxial double-tubular compliant grafts were implanted into the canine common carotid arteries in an end-to-end fashion for up to 12 months. The overall patency rate was 86% (24/28), and neither rupture nor aneurysmal formation was observed. A neoarterial wall was formed via transanastomotic and transmural tissue ingrowth, resulting in neoarterial tissue formation on the luminal surface and into the intertubular space of the double-tubular graft, accompanied by mainly myofibroblasts and inflammatory cells in the early stage and endothelialization and collagen-rich extracellular matrices in the late stage of implantation. Surrounding-tissue adhesion with the outer tube was prevented by the hydrophilic polymer coating. Although the J curve of the implanted prototype model was preserved 1 month after implantation, the impaired J curves were observed because of tissue ingrowth and tissue adhesion between the outer surface of the inner tube and the surrounding tissues 3 and 6 months after implantation. At 12 months after implantation, however, the implanted coaxial double-tubular graft exhibited high compliance due to biodegradation of the SPU films.
影响因子：
4.2
作者：
Qiu, YC;Tarbell, JM
通讯作者：
Tarbell, JM
关于犬颈动脉和聚氨酯移植物之间的匹配顺应性。
影响因子：
2.4
作者：
Hsu,S;Kambic,H
通讯作者：
Kambic,H