Exploration of lung mycobiome in the patients with non-small-cell lung cancer.
Exploration of lung mycobiome in the patients with non-small-cell lung cancer.
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DOI：
10.1186/s12866-023-02790-4
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发表时间：
2023-03-25
期刊：
影响因子：
4.2
通讯作者：
Tang, Jingqun
中科院分区：
文献类型：
--
作者：
Zhao, Yiming;Yi, Junqi;Xiang, Juanjuan;Jia, Wei;Chen, Anqi;Chen, Liyu;Zheng, Leliang;Zhou, Wen;Wu, Minghua;Yu, Zheng;Tang, Jingqun
随着人类微生物组计划（HMP）的进展，微生物与人类健康的关系越来越受到关注。越来越多的报告支持癌症与微生物之间的相关性。然而，大多数研究都集中在细菌，而不是真菌群落。在这项研究中，我们使用宏基因组测序和qPCR研究了非小细胞肺癌（NSCLC）患者肺部真菌组的变化。非小细胞肺癌患者的真菌多样性更高，网络更复杂。此外，发现与NSCLC最相关的真菌是Alternaria arborescens，并且还检测到其在癌组织中的富集。本研究提示真菌群落的变化可能与肺癌密切相关，为进一步探讨肺癌与真菌的关系提供了思路。在线版本包含补充材料，可通过10.1186/s12866-023-02790-4获得
As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied the alteration in lung mycobiome in patients with non-small-cell lung cancer (NSCLC) using metagenomic sequencing and qPCR. The higher fungal diversity and more complex network were observed in the patients with NSCLC. In addition, Alternaria arborescens was found as the most relevant fungus to NSCLC, and the enrichment of it in cancerous tissue was also detected. This study proposes that the changes in fungal communities may be closely related to lung cancer, and provides insights into further exploration the relationship between lung cancer and fungi. The online version contains supplementary material available at 10.1186/s12866-023-02790-4
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