Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.
Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.
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DOI：
10.1136/bmjopen-2020-045286
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发表时间：
2021-04-07
期刊：
影响因子：
2.9
通讯作者：
Hippisley-Cox J
中科院分区：
文献类型：
--
作者：
Dambha-Miller H;Tan PS;Saatci D;Clift AK;Zaccardi F;Coupland C;Locufier P;Davies F;Khunti K;Griffin SJ;Hippisley-Cox J
最近的证据表明，少数族裔群体因SARS-CoV-2感染住院和死亡的风险不成比例地增加。缺乏基于人口的证据，说明少数群体和亚群体之间的潜在解释因素。本研究旨在量化种族与COVID-19导致的住院和死亡风险之间的关联。这是一项回顾性队列研究，研究对象是在代表性和匿名的国家初级保健数据库（QResearch）中注册的成年人，该数据库包括英格兰1000万人的数据。将总结社会人口统计学、贫困、临床和住所特征，并在种族亚组之间进行比较（根据2011年人口普查分类）。将使用考克斯模型计算与种族组相关的住院和COVID-19死亡率的HR。将在回归模型中调整潜在混杂和解释因素（如人口统计学、社会经济学和临床）。将计算不同风险因素类别对种族组/亚组中观察到的超额风险的贡献百分比。根据QResearch协议（参考OX 102），对本研究进行了伦理审查。研究结果将通过同行审查的手稿、在科学会议上的介绍以及与国家和国际利益攸关方举行的会议进行传播。
Recent evidence suggests that ethnic minority groups are disproportionately at increased risk of hospitalisation and death from SARS-CoV-2 infection. Population-based evidence on potential explanatory factors across minority groups and within subgroups is lacking. This study aims to quantify the association between ethnicity and the risk of hospitalisation and mortality due to COVID-19. This is a retrospective cohort study of adults registered across a representative and anonymised national primary care database (QResearch) that includes data on 10 million people in England. Sociodemographic, deprivation, clinical and domicile characteristics will be summarised and compared across ethnic subgroups (categorised as per 2011 census). Cox models will be used to calculate HR for hospitalisation and COVID-19 mortality associated with ethnic group. Potential confounding and explanatory factors (such as demographic, socioeconomic and clinical) will be adjusted for within regression models. The percentage contribution of distinct risk factor classes to the excess risks seen in ethnic groups/subgroups will be calculated. The study has undergone ethics review in accordance with the QResearch agreement (reference OX102). Findings will be disseminated through peer-reviewed manuscripts, presentations at scientific meetings and conferences with national and international stakeholders.
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影响因子：
29
作者：
Zhu, Lihua;She, Zhi-Gang;Li, Hongliang
通讯作者：
Li, Hongliang
DOI：
10.1136/heartjnl-2020-317393
发表时间：
2020-10
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Hippisley-Cox J;Young D;Coupland C;Channon KM;Tan PS;Harrison DA;Rowan K;Aveyard P;Pavord ID;Watkinson PJ
通讯作者：
Watkinson PJ
DOI：
10.1136/bmj.m3731
发表时间：
2020-10-20
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Clift AK;Coupland CAC;Keogh RH;Diaz-Ordaz K;Williamson E;Harrison EM;Hayward A;Hemingway H;Horby P;Mehta N;Benger J;Khunti K;Spiegelhalter D;Sheikh A;Valabhji J;Lyons RA;Robson J;Semple MG;Kee F;Johnson P;Jebb S;Williams T;Hippisley-Cox J
通讯作者：
Hippisley-Cox J
影响因子：
15.8
作者：
Benchimol EI;Smeeth L;Guttmann A;Harron K;Moher D;Petersen I;Sørensen HT;von Elm E;Langan SM;RECORD Working Committee
通讯作者：
RECORD Working Committee
DOI：
10.1016/j.jclinepi.2007.11.008
发表时间：
2007-11-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
von Elm, Erik;Altman, Douglas G;Vandenbroucke, Jan P
通讯作者：
Vandenbroucke, Jan P