Ionizing radiation-induced circulatory and metabolic diseases.
Ionizing radiation-induced circulatory and metabolic diseases.
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DOI：
10.1016/j.envint.2020.106235
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发表时间：
2021-01
影响因子：
11.8
通讯作者：
Salomaa, Sisko
中科院分区：
文献类型：
--
作者：
Tapio, Soile;Little, Mark P.;Kaiser, Jan Christian;Impens, Nathalie;Hamada, Nobuyuki;Georgakilas, Alexandros G.;Simar, David;Salomaa, Sisko
关键词：
对健康的风险是所有人类电离辐射暴露情况下的首要考虑因素，因此与所有职业、医疗和公共暴露情况下的辐射防护相关。在过去的几十年里，治疗策略的进步导致了癌症存活率的显著提高。然而，据报道，癌症幸存者中有各种各样的长期并发症，特别是循环系统疾病及其主要危险因素代谢疾病。然而，在较低的暴露水平下，证据就不那么清楚了。在包括放射治疗在内的现实照射情景下，整个生物体中的辐射效应主要由正常组织在接受相对低剂量时的反应决定，并由全身效应介导和调节。因此，迫切需要进一步研究低剂量辐射的影响。在本文中，我们回顾了循环和代谢疾病的辐射相关风险，涉及流行病学，生物学，风险建模和系统生物学方面，强调了知识上的差距，并讨论了解决这些差距的未来方向。
Risks to health are the prime consideration in all human situations of ionizing radiation exposure and therefore of relevance to radiation protection in all occupational, medical, and public exposure situations. Over the past few decades, advances in therapeutic strategies have led to significant improvements in cancer survival rates. However, a wide range of long-term complications have been reported in cancer survivors, in particular circulatory diseases and their major risk factors, metabolic diseases. However, at lower levels of exposure, the evidence is less clear. Under real-life exposure scenarios, including radiotherapy, radiation effects in the whole organism will be determined mainly by the response of normal tissues receiving relatively low doses, and will be mediated and moderated by systemic effects. Therefore, there is an urgent need for further research on the impact of low-dose radiation. In this article, we review radiation-associated risks of circulatory and metabolic diseases, addressing epidemiological, biological, risk modelling, and systems biology aspects, highlight the gaps in knowledge and discuss future directions to address these gaps.
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