Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis.
Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: Pathophysiology, Assessment, Prevalence and Prognosis.
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DOI：
10.15420/cfr.2022.12
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发表时间：
2022-01
影响因子：
--
通讯作者：
Kanagala, Prathap
中科院分区：
文献类型：
--
作者：
Bilak, Joanna M.;Alam, Uazman;Miller, Christopher A.;McCann, Gerry P.;Arnold, Jayanth R.;Kanagala, Prathap
关键词：
保留射血分数的心力衰竭（HFpEF）目前约占社区所有新心力衰竭病例的一半。HFpEF与慢性生活方式相关疾病密切相关，如肥胖和2型糖尿病，有合并症的患者的临床结果比没有合并症的患者更差。HFpEF在病理生理学上不同于射血分数降低的心力衰竭，这可能部分解释了两种心力衰竭表型之间可用治疗方案的差异。HFpEF的机制是复杂的，冠状动脉微血管功能障碍（MVD）被认为是其病理生理的潜在关键驱动因素。在这篇综述中，作者强调了MVD在HFpEF病理生理学中的证据，MVD的诊断方法（包括侵入性和非侵入性）以及MVD的患病率和预后意义。
Heart failure with preserved ejection fraction (HFpEF) currently accounts for approximately half of all new heart failure cases in the community. HFpEF is closely associated with chronic lifestyle-related diseases, such as obesity and type 2 diabetes, and clinical outcomes are worse in those with than without comorbidities. HFpEF is pathophysiologically distinct from heart failure with reduced ejection fraction, which may explain, in part, the disparity of treatment options available between the two heart failure phenotypes. The mechanisms underlying HFpEF are complex, with coronary microvascular dysfunction (MVD) being proposed as a potential key driver in its pathophysiology. In this review, the authors highlight the evidence implicating MVD in HFpEF pathophysiology, the diagnostic approaches for identifying MVD (both invasive and non-invasive) and the prevalence and prognostic significance of MVD.
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影响因子：
--
作者：
Blackledge, HM;Newton, J;Squire, IB
通讯作者：
Squire, IB
DOI：
10.1007/s10554-020-01953-y
发表时间：
2021-01
期刊：
The international journal of cardiovascular imaging
影响因子：
--
作者：
Kanagala P;Arnold JR;Singh A;Khan JN;Gulsin GS;Gupta P;Squire IB;Ng LL;McCann GP
通讯作者：
McCann GP
影响因子：
--
作者：
Ariyaratnam, Jonathan P;Lau, Dennis H;Kalman, Jonathan M
通讯作者：
Kalman, Jonathan M
影响因子：
16.2
作者：
Gulsin, Gaurav S.;Henson, Joseph;McCann, Gerry P.
通讯作者：
McCann, Gerry P.
影响因子：
16.2
作者：
Gulsin, Gaurav S.;Swarbrick, Daniel J.;McCann, Gerry P.
通讯作者：
McCann, Gerry P.