Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy.
Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy.
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DOI：
10.1016/j.jconrel.2015.09.063
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发表时间：
2015-12-10
期刊：
影响因子：
--
通讯作者：
Roy K
中科院分区：
文献类型：
--
作者：
Leleux J;Atalis A;Roy K
虽然已经针对许多病原体开发了成功的疫苗，但仍有许多疾病和病原性感染对当前的疫苗接种策略高度回避。因此，必须开发更复杂的方法来控制疫苗诱导的免疫反应的类型和质量。树突状细胞(DC)是机体的前哨细胞，通过连接先天免疫和获得性免疫，在免疫反应的产生和导向中发挥关键作用。现在人们已经认识到，发展中国家可以分为许多小组，每个小组都有独特的功能。更好地了解淋巴器官和外周的各种DC亚群如何通过受控递送来靶向；以及这些亚群如何调节和控制由此产生的免疫反应，可以极大地增强我们开发针对复杂疾病的新的有效疫苗的能力。在这篇综述中，我们提供了DC亚群生物学的概述，并讨论了目前利用DC靶向来调节和控制免疫反应的免疫治疗策略。
While successful vaccines have been developed against many pathogens, there are still many diseases and pathogenic infections that are highly evasive to current vaccination strategies. Thus, more sophisticated approaches to control the type and quality of vaccine-induced immune response must be developed. Dendritic cells (DCs) are the sentinels of the body and play a critical role in immune response generation and direction by bridging innate and adaptive immunity. It is now well recognized that DCs can be separated into many subgroups, each of which has a unique function. Better understanding of how various DC subsets, in lymphoid organs and in the periphery, can be targeted through controlled delivery; and how these subsets modulate and control the resulting immune response could greatly enhance our ability to develop new, effective vaccines against complex diseases. In this review, we provide an overview of DC subset biology and discuss current immunotherapeutic strategies that utilize DC targeting to modulate and control immune responses.
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DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
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