Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population.
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关联分析确定了中国人群中多个新的肺癌易感位点及其与吸烟的相互作用
DOI：
10.1038/ng.2351
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发表时间：
2012-07-15
期刊：
影响因子：
30.8
通讯作者：
Shen H
中科院分区：
文献类型：
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作者：
Dong J;Hu Z;Wu C;Guo H;Zhou B;Lv J;Lu D;Chen K;Shi Y;Chu M;Wang C;Zhang R;Dai J;Jiang Y;Cao S;Qin Z;Yu D;Ma H;Jin G;Gong J;Sun C;Zhao X;Yin Z;Yang L;Li Z;Deng Q;Wang J;Wu W;Zheng H;Zhou G;Chen H;Guan P;Peng Z;Chen Y;Shu Y;Xu L;Liu X;Liu L;Xu P;Han B;Bai C;Zhao Y;Zhang H;Yan Y;Amos CI;Chen F;Tan W;Jin L;Wu T;Lin D;Shen H
为了找到肺癌的其他易感基因座，我们在7，436名肺癌患者（病例）和7，483名对照的扩展验证样本量中，对我们之前在中国人群中进行的肺癌全基因组关联研究（GWAS）中的有希望的关联进行了测试。我们发现全基因组范围内（P< 5.0 × 10−8）在10 p14上有三个额外的肺癌易感基因座的证据（rs 1663689，接近GATA 3，P= 2.84 × 10−10），5 q32（rs 2895680，PPP 2 R2 B-STK 32A-DPYSL 3，P= 6.60 × 10−9）和20q13.2（rs 4809957，CYP 24 A1，P= 1.20 × 10−8）。我们还发现5q31.1处的rs 247008（IL 3-CSF 2-P4 HA 2，P= 7.68 × 10−8）和1p36.32处的rs 9439519（AJAP 1-NPHP 4，P= 3.65 × 10−6）具有一致的相关性。其中4个位点显示出与吸烟剂量相互作用的证据（rs 2895680、rs 4809957、rs 247008和rs 9439519的P= 1.72 × 10−10、P= 5.07 × 10 − 3、P= 6.77 × 10− 3和P = 4.49 × 10− 2）。这些结果推进了我们对肺癌易感性的理解，并突出了在肺癌发展中整合遗传变异和吸烟的潜在途径。
To find additional susceptibility loci for lung cancer, we tested promising associations from our previous genome-wide association study (GWAS) of lung cancer in the Chinese population in an extended validation sample size of 7,436 individuals with lung cancer (cases) and 7,483 controls. We found genome-wide significant (P< 5.0 × 10−8) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close toGATA3,P= 2.84 × 10−10), 5q32 (rs2895680 inPPP2R2B-STK32A-DPYSL3,P= 6.60 × 10−9) and 20q13.2 (rs4809957 inCYP24A1,P= 1.20 × 10−8). We also found consistent associations for rs247008 at 5q31.1 (IL3-CSF2-P4HA2,P= 7.68 × 10−8) and rs9439519 at 1p36.32 (AJAP1-NPHP4,P= 3.65 × 10−6). Four of these loci showed evidence for interactions with smoking dose (P= 1.72 × 10−10,P= 5.07 × 10−3,P= 6.77 × 10−3andP= 4.49 × 10−2for rs2895680, rs4809957, rs247008 and rs9439519, respectively). These results advance our understanding of lung cancer susceptibility and highlight potential pathways that integrate genetic variants and smoking in the development of lung cancer.
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影响因子：
30.8
作者：
通讯作者：
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影响因子：
30.8
作者：
McKay, James D.;Hung, Rayjean J.;Gaborieau, Valerie;Boffetta, Paolo;Chabrier, Amelie;Byrnes, Graham;Zaridze, David;Mukeria, Anush;Szeszenia-Dabrowska, Neonilia;Lissowska, Jolanta;Rudnai, Peter;Fabianova, Eleonora;Mates, Dana;Bencko, Vladimir;Foretova, Lenka;Janout, Vladimir;McLaughlin, John;Shepherd, Frances;Montpetit, Alexandre;Narod, Steven;Krokan, Hans E.;Skorpen, Frank;Elvestad, Maiken Bratt;Vatten, Lars;Njolstad, Inger;Axelsson, Tomas;Chen, Chu;Goodman, Gary;Barnett, Matt;Loomis, Melissa M.;Lubinski, Jan;Matyjasik, Joanna;Lener, Marcin;Oszutowska, Dorota;Field, John;Liloglou, Triantafillos;Xinarianos, George;Cassidy, Adrian;Zelenika, Diana;Boland, Anne;Delepine, Marc;Foglio, Mario;Lechner, Doris;Matsuda, Fumihiko;Blanche, Helene;Gut, Ivo;Heath, Simon;Lathrop, Mark;Brennan, Paul
通讯作者：
Brennan, Paul
DOI：
10.1083/jcb.201009069
发表时间：
2011-05-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Habbig S;Bartram MP;Müller RU;Schwarz R;Andriopoulos N;Chen S;Sägmüller JG;Hoehne M;Burst V;Liebau MC;Reinhardt HC;Benzing T;Schermer B
通讯作者：
Schermer B
影响因子：
5.3
作者：
Asselin-Labat, Marie-Liesse;Sutherland, Kate D.;Visvader, Jane E.
通讯作者：
Visvader, Jane E.
影响因子：
11.2
作者：
Kim, Bumjin;Lee, Hyun Joo;Lee, Sanghyuk
通讯作者：
Lee, Sanghyuk