Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson's and Alzheimer's Diseases: a Review.
Current Aspects of the Endocannabinoid System and Targeted THC and CBD Phytocannabinoids as Potential Therapeutics for Parkinson's and Alzheimer's Diseases: a Review.
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DOI：
10.1007/s12035-020-02054-6
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发表时间：
2020-11
影响因子：
5.1
通讯作者：
Suphioglu C
中科院分区：
文献类型：
--
作者：
Cooray R;Gupta V;Suphioglu C
导致帕金森氏病(PD)和阿尔茨海默病(AD)的神经变性已成为全球主要的健康负担。目前的治疗主要以控制症状为主，临床上尚无预防神经变性或诱导神经元修复的治疗方法。因此，对这两种疾病进行新的研究势在必行。这篇文献综述旨在提供关于帕金森病和阿尔茨海默病的已发表工作的集合，以及内源性大麻系统(ECS)作为治疗神经退行性变的潜在药物靶点的当前用途。帕金森病的治疗通常采用L多巴和脑深部电刺激。最近的基因修饰和重塑技术，如通过人类胚胎干细胞和诱导多能干细胞的CRISPR，已经显示出个性化药物的有前途的策略。以细胞外沉积的淀粉样蛋白、β老年斑和tau蛋白的神经纤维缠结为特征的AD通常使用胆碱乙酰转移酶增强剂作为治疗药物。目前，ECS被作为PD和AD的药物靶点进行研究，其中ECS受体的过度表达对PD具有神经保护作用，并减少AD的神经炎症。植物大麻的β-9-四氢大麻碱(Δ-9-THC)和大麻二酚(CBD)大麻素类化合物对PD和AD动物模型具有神经保护作用，但直接给药时会对患者产生毒性作用。因此，建议了解大麻类药物治疗后的精确分子级联，特别是关注基因表达，以确定预防和修复神经退行性变的药物靶点。
Neurodegeneration leading to Parkinson’s disease (PD) and Alzheimer’s disease (AD) has become a major health burden globally. Current treatments mainly target controlling symptoms and there are no therapeutics available in clinical practice to preventing the neurodegeneration or inducing neuronal repairing. Thus, the demand of novel research for the two disorders is imperative. This literature review aims to provide a collection of published work on PD and AD and current uses of endocannabinoid system (ECS) as a potential drug target for neurodegeneration. PD is frequently treated with l-DOPA and deep brain stimulation. Recent gene modification and remodelling techniques, such as CRISPR through human embryonic stem cells and induced pluripotent stem cells, have shown promising strategy for personalised medicine. AD characterised by extracellular deposits of amyloid β-senile plaques and neurofibrillary tangles of tau protein commonly uses choline acetyltransferase enhancers as therapeutics. The ECS is currently being studied as PD and AD drug targets where overexpression of ECS receptors exerted neuroprotection against PD and reduced neuroinflammation in AD. The delta-9-tetrahydrocannabinoid (Δ9-THC) and cannabidiol (CBD) cannabinoids of plant Cannabis sativa have shown neuroprotection upon PD and AD animal models yet triggered toxic effects on patients when administered directly. Therefore, understanding the precise molecular cascade following cannabinoid treatment is suggested, focusing especially on gene expression to identify drug targets for preventing and repairing neurodegeneration.
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影响因子：
5.8
作者：
Doris, Joseph M.;Millar, Sophie A.;O'Sullivan, Saoirse E.
通讯作者：
O'Sullivan, Saoirse E.
影响因子：
11.2
作者：
Abou-Sleiman, PM;Healy, DG;Wood, NW
通讯作者：
Wood, NW
影响因子：
4
作者：
Cao, Chuanhai;Li, Yaqiong;Cai, Jianfeng
通讯作者：
Cai, Jianfeng
影响因子：
4
作者：
Cheng, David;Spiro, Adena S.;Karl, Tim
通讯作者：
Karl, Tim
影响因子：
15.1
作者：
Efthymiou AG;Goate AM
通讯作者：
Goate AM