Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer.
Long intergenic non-coding RNA 271 is predictive of a poorer prognosis of papillary thyroid cancer.
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长基因间非编码 RNA 271 预示着甲状腺乳头状癌的较差预后
DOI：
10.1038/srep36973
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发表时间：
2016-11-11
影响因子：
4.6
通讯作者：
Ji Q
中科院分区：
文献类型：
--
作者：
Ma B;Liao T;Wen D;Dong C;Zhou L;Yang S;Wang Y;Ji Q
已经发现许多长链非编码RNA（lncRNA）在肿瘤发生和肿瘤进展中起关键作用。我们的目的是研究lncRNA是否可以作为甲状腺乳头状癌（PTC）的预后生物标志物，这可能有助于我们评估患者的疾病状态和预后。我们在癌症基因组图谱（TCGA）数据集中从HUGO基因命名委员会批准的注释的2773个lncRNA中发现了220个表达改变的lncRNA，其中FAM 41 C、CTBP 1-AS 2、LINC 00271、HAR 1A、LINC 00310和HAS 2-AS 1与复发相关。多因素分析显示，LINC 00271是甲状腺外浸润、淋巴结转移、晚期肿瘤III/IV期和复发的独立危险因素。此外，LINC 00271在PTC中的表达与癌旁正常组织相比显著下调（P < 0.001）。基因集富集分析（Gene Set Enrichment Analysis，GSEA）显示，与细胞粘附分子、细胞周期、P53信号通路和JAK/STAT信号通路相关的基因在低LINC 00271组中明显富集，而在高LINC 00271组中则明显富集。因此，LINC 00271可能是PTC的一个抑癌基因，它可能是PTC预后不良的一个潜在预测因子。
A number of long non-coding RNAs (lncRNAs) have been found to play critical roles in oncogenesis and tumor progression. We aimed to investigate whether lncRNAs could act as prognostic biomarkers for papillary thyroid cancer (PTC) that may assist us in evaluating disease status and prognosis for patients. We found 220 lncRNAs with expression alteration from the annotated 2773 lncRNAs approved by the HUGO gene nomenclature committee in The Cancer Genome Atlas (TCGA) dataset, of which FAM41C, CTBP1-AS2, LINC00271, HAR1A, LINC00310 and HAS2-AS1 were associated with recurrence. After adjusting classical clinicopathogical factors andBRAFV600Emutation, LINC00271 was found to be an independent risk factor for extrathyroidal extension, lymph node metastasis, advanced tumor stage III/IV and recurrence in multivariate analyses. Additionally, LINC00271 expression was significantly downregulated in PTCs versus adjacent normal tissues (P < 0.001). The Gene Set Enrichment Analysis (GSEA) revealed that genes associated with cell adhesion molecules, cell cycle, P53 signaling pathway and JAK/STAT signaling pathway were remarkably enriched in lower-LINC00271 versus higher-LINC00271 tumors. In conclusion, LINC00271 was identified as a possible suppressor gene in PTC in our study, and it may serve as a potential predictor of poor prognoses in PTC.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
64.5
作者：
Huarte M;Guttman M;Feldser D;Garber M;Koziol MJ;Kenzelmann-Broz D;Khalil AM;Zuk O;Amit I;Rabani M;Attardi LD;Regev A;Lander ES;Jacks T;Rinn JL
通讯作者：
Rinn JL
影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.5
作者：
Kapoor A;Yao W;Ying H;Hua S;Liewen A;Wang Q;Zhong Y;Wu CJ;Sadanandam A;Hu B;Chang Q;Chu GC;Al-Khalil R;Jiang S;Xia H;Fletcher-Sananikone E;Lim C;Horwitz GI;Viale A;Pettazzoni P;Sanchez N;Wang H;Protopopov A;Zhang J;Heffernan T;Johnson RL;Chin L;Wang YA;Draetta G;DePinho RA
通讯作者：
DePinho RA