Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage.
Fusobacterium nucleatum infection correlates with two types of microsatellite alterations in colorectal cancer and triggers DNA damage.
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DOI：
10.1186/s13099-020-00384-3
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发表时间：
2020
期刊：
影响因子：
4.2
通讯作者：
Carethers JM
中科院分区：
文献类型：
--
作者：
Okita Y;Koi M;Takeda K;Ross R;Mukherjee B;Koeppe E;Stoffel EM;Galanko JA;McCoy AN;Keku TO;Okugawa Y;Kitajima T;Toiyama Y;Martens E;Carethers JM
核梭杆菌（Fusobacterium nucleatum, Fn）常见于结直肠癌（colorectal cancer, crc）。在微卫星不稳定性高（MSI-H）或CpG岛高甲基化表型（CIMP）的结直肠癌组织中检测到高负荷的Fn DNA。Fn感染也与结直肠癌的炎性肿瘤微环境有关。CRC的一种亚型表现为炎症相关的微卫星改变（IAMA），其特征是微卫星不稳定性低（MSI-L）和/或在选定的四核苷酸重复序列（EMAST）上微卫星改变水平升高。在这里，我们描述了两个独立的CRC队列，其中Fn DNA的重负荷或中等负荷分别与MSI-H和L/E CRC相关。我们也证明Fn在感染细胞中产生诱导γ-H2AX的因子，这是DNA双链断裂（DSBs）的标志。
Fusobacterium nucleatum (Fn) is frequently found in colorectal cancers (CRCs). High loads of Fn DNA are detected in CRC tissues with microsatellite instability-high (MSI-H), or with the CpG island hypermethylation phenotype (CIMP). Fn infection is also associated with the inflammatory tumor microenvironment of CRC. A subtype of CRC exhibits inflammation-associated microsatellite alterations (IAMA), which are characterized by microsatellite instability-low (MSI-L) and/or an elevated level of microsatellite alterations at selected tetra-nucleotide repeats (EMAST). Here we describe two independent CRC cohorts in which heavy or moderate loads of Fn DNA are associated with MSI-H and L/E CRC respectively. We also show evidence that Fn produces factors that induce γ-H2AX, a hallmark of DNA double strand breaks (DSBs), in the infected cells.
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影响因子：
24.5
作者：
Mima K;Nishihara R;Qian ZR;Cao Y;Sukawa Y;Nowak JA;Yang J;Dou R;Masugi Y;Song M;Kostic AD;Giannakis M;Bullman S;Milner DA;Baba H;Giovannucci EL;Garraway LA;Freeman GJ;Dranoff G;Garrett WS;Huttenhower C;Meyerson M;Meyerhardt JA;Chan AT;Fuchs CS;Ogino S
通讯作者：
Ogino S
结肠菌群和大肠癌的分子特征中的梭杆菌。
影响因子：
11.2
作者：
Tahara T;Yamamoto E;Suzuki H;Maruyama R;Chung W;Garriga J;Jelinek J;Yamano HO;Sugai T;An B;Shureiqi I;Toyota M;Kondo Y;Estécio MR;Issa JP
通讯作者：
Issa JP
DOI：
10.1007/s11605-010-1340-6
发表时间：
2010-10
期刊：
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
影响因子：
--
作者：
Devaraj B;Lee A;Cabrera BL;Miyai K;Luo L;Ramamoorthy S;Keku T;Sandler RS;McGuire KL;Carethers JM
通讯作者：
Carethers JM
DOI：
10.1126/science.aal5240
发表时间：
2017-12-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bullman S;Pedamallu CS;Sicinska E;Clancy TE;Zhang X;Cai D;Neuberg D;Huang K;Guevara F;Nelson T;Chipashvili O;Hagan T;Walker M;Ramachandran A;Diosdado B;Serna G;Mulet N;Landolfi S;Ramon Y Cajal S;Fasani R;Aguirre AJ;Ng K;Élez E;Ogino S;Tabernero J;Fuchs CS;Hahn WC;Nuciforo P;Meyerson M
通讯作者：
Meyerson M
影响因子：
3.6
作者：
Munakata, Koji;Koi, Minoru;Carethers, John M.
通讯作者：
Carethers, John M.