Development of Photoacoustic Probes for in Vivo Molecular Imaging.

Development of Photoacoustic Probes for in Vivo Molecular Imaging.
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DOI:
10.1021/acs.biochem.7b00888
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发表时间:
2018-01-16
期刊:
影响因子:
2.9
通讯作者:
Chan J
Chan J
中科院分区:
生物学3区
文献类型:
--
作者:
Reinhardt CJ;Chan J

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光声(PA)成像是一种新兴的,非侵入性的成像方式,包括光学和超声成像的属性。由于光激发和声检测的组合,PA成像能够在深层组织(厘米深度)内实现高对比度和高分辨率。PA探针开发的最新进展允许在各种生物模型中进行刺激响应成像,这对基础科学、转化科学和临床科学都有影响。这一观点强调了PA探针的发展及其应用于活体动物分子成像的最新进展。
Photoacoustic (PA) imaging is an emerging, non-invasive imaging modality that encompasses attributes of both optical and ultrasound imaging. Because of the combination of optical excitation and acoustic detection, PA imaging enables high contrast and high resolution within deep tissue (centimeter depths). Recent advances in PA probe development have allowed for stimulus-responsive imaging in a variety of biological models with implications for basic, translational, and clinical sciences. This perspective highlights recent progress in the development of PA probes and their application to live-animal molecular imaging.
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