Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer
Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer
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晚期胃癌脊柱转移瘤采用多模式治疗无需手术即可成功实现神经功能恢复
DOI：
10.1155/2020/4753027
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yonemoto T.
中科院分区：
文献类型：
--
作者：
Kinoshita H;Kamoda H;Ishii T;Hagiwara Y;Tsukanishi T;Orita S;Inage K;Hirosawa N;Ohtori S;Yonemoto T.
摘要骨促结缔组织增生性纤维瘤是一种非常罕见的原发性良性骨肿瘤，好发于30岁以下的病人。作为推荐的DFB主要治疗方法，从复发的角度来看，广泛切除术优于刮除术，但在骨盆（如髋臼）广泛切除DFB可能导致更大的功能丧失，这表明需要保守治疗。然而，尚无关于DFB保守治疗后长期随访的报告。本病例涉及一名21岁女性，右髋疼痛。放射学评价显示右侧髂骨和髋臼有大量病变，伴部分骨溶解、皮质破坏、边缘硬化、轻微假骨小梁形成和骨膨胀。髂骨切开活检显示梭形细胞在丰富的胶原基质中增殖，无细胞分裂和有丝分裂，提示诊断为DFB。考虑到广泛髂骨切除后更大的功能丧失风险，选择保守治疗。随访10年后的评价显示髂骨部分硬化病变，无疼痛。目前的情况表明，保守治疗可能是有效的，即使在某些情况下，积极的DFB。
Desmoplastic fibroma of the bone (DFB) is a notably rare, lytic, locally aggressive but nonmetastatic, primary benign bone tumor in patients less than 30 years old. As the recommended primary treatment for DFB, wide resection is preferred to curettage from the perspective of recurrence but wide resection of DFB in the pelvis such as in the acetabulum could result in greater functional loss, suggesting the need for conservative treatments. However, there is no report on long‐term follow‐up following conservative treatment for DFB. The present case involved a 21‐year‐old woman with right hip pain. Radiological evaluation revealed a massive lesion throughout the right ilium and acetabulum with partial osteolysis, cortical destruction, marginal sclerosis, slight pseudotrabeculation, and bone expansion. Open biopsy from the ilium showed the proliferation of spindle cells in an abundant collagenous matrix without atypia and mitosis, suggesting a diagnosis of DFB. Conservative treatment was selected considering the risk of greater functional loss following wide ilium resection. An evaluation 10 years after follow‐up showed a partially sclerotic lesion of the ilium and the absence of pain. The current case demonstrates that conservative therapy may be effective even in some cases of aggressive DFB.
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DOI：
--
发表时间：
2018
期刊：
Gan to kagaku ryoho. Cancer & chemotherapy
影响因子：
--
作者：
Yu Misao;O. Tanaka;Kengo Ichikawa;M. Tawada;M. Kume
通讯作者：
M. Kume
影响因子：
3.7
作者：
Daniel JW;Veiga JC
通讯作者：
Veiga JC
影响因子：
2.9
作者：
Gomi D;Fukushima T;Kobayashi T;Sekiguchi N;Sakamoto A;Mamiya K;Koizumi T
通讯作者：
Koizumi T
影响因子：
3
作者：
Catz, A;Thaleisnik, M;Gepstein, R
通讯作者：
Gepstein, R
唑来膦酸的剂量及其在乳腺癌中的抗肿瘤作用。
影响因子：
3.4
作者：
Zhao X;Hu X
通讯作者：
Hu X