Lysophospholipid Mediators in Health and Disease.
Lysophospholipid Mediators in Health and Disease.
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健康和疾病中的溶血磷脂介质。
DOI：
10.1146/annurev-pathol-050420-025929
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发表时间：
2022-01-24
期刊：
影响因子：
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中科院分区：
文献类型：
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Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolism and perturbation of biological membranes. Both molecules are established extracellular lipid mediators that signal via specific G protein–coupled receptors in vertebrates. This widespread signaling axis regulates the development, physiological functions, and pathological processes of all organ systems. Indeed, recent research into LPA and S1P has revealed their important roles in cellular stress signaling, inflammation, resolution, and host defense responses. In this review, we focus on how LPA regulates fibrosis, neuropathic pain, abnormal angiogenesis, endometriosis, and disorders of neuroectodermal development such as hydrocephalus and alopecia. In addition, we discuss how S1P controls collective behavior, apoptotic cell clearance, and immunosurveillance of cancers. Advances in lysophospholipid research have led to new therapeutics in autoimmune diseases, with many more in earlier stages of development for a wide variety of diseases, such as fibrotic disorders, vascular diseases, and cancer.
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影响因子：
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作者：
Fransen, Marieke F.;Schoonderwoerd, Mark;Ossendorp, Ferry
通讯作者：
Ossendorp, Ferry
在硬皮病小鼠模型中通过基因缺失或溶血磷脂酸受体 1 的药理学拮抗作用改善真皮纤维化。
影响因子：
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作者：
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通讯作者：
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DOI：
10.1161/atvbaha.120.305565
发表时间：
2021-03
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Engelbrecht E;MacRae CA;Hla T
通讯作者：
Hla T
影响因子：
4.8
作者：
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