Animal models of diabetic retinopathy: summary and comparison.
Animal models of diabetic retinopathy: summary and comparison.
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DOI：
10.1155/2013/106594
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发表时间：
2013
影响因子：
4.3
通讯作者：
Lo AC
中科院分区：
文献类型：
--
作者：
Lai AK;Lo AC
糖尿病视网膜病变（DR）是一种与慢性高血糖暴露相关的微血管并发症，是全世界失明的主要原因。虽然糖尿病患者的临床评估和视网膜解剖提供了DR的特征和进展信息，但其潜在的病理生理机制无法推断。为了更好地了解DR在分子和细胞水平上的发展，人们开发了各种动物模型。它们包括药物诱导高血糖和自发性糖尿病啮齿动物，以及无糖尿病的血管生成模型（以补偿增殖性DR症状的缺失）。在这篇综述中，我们总结了现有的STZ诱导糖尿病的方案。我们还描述和比较了目前可用的DR动物模型在形态学和功能方面的病理表现。本文还讨论了从斑马鱼、啮齿动物到其他高级哺乳动物等不同动物的优缺点。到目前为止，还没有一种单一的模型能像在人类身上看到的那样显示出DR的所有临床特征。然而，随着对这些动物模型病理结果的了解，研究人员可以选择最合适的模型进行机制研究或药物筛选。
Diabetic retinopathy (DR) is a microvascular complication associated with chronic exposure to hyperglycemia and is a major cause of blindness worldwide. Although clinical assessment and retinal autopsy of diabetic patients provide information on the features and progression of DR, its underlying pathophysiological mechanism cannot be deduced. In order to have a better understanding of the development of DR at the molecular and cellular levels, a variety of animal models have been developed. They include pharmacological induction of hyperglycemia and spontaneous diabetic rodents as well as models of angiogenesis without diabetes (to compensate for the absence of proliferative DR symptoms). In this review, we summarize the existing protocols to induce diabetes using STZ. We also describe and compare the pathological presentations, in both morphological and functional aspects, of the currently available DR animal models. The advantages and disadvantages of using different animals, ranging from zebrafish, rodents to other higher-order mammals, are also discussed. Until now, there is no single model that displays all the clinical features of DR as seen in human. Yet, with the understanding of the pathological findings in these animal models, researchers can select the most suitable models for mechanistic studies or drug screening.
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影响因子：
--
作者：
Alvarez Y;Cederlund ML;Cottell DC;Bill BR;Ekker SC;Torres-Vazquez J;Weinstein BM;Hyde DR;Vihtelic TS;Kennedy BN
通讯作者：
Kennedy BN
影响因子：
15.9
作者：
Barber, AJ;Lieth, E;Gardner, TW
通讯作者：
Gardner, TW
影响因子：
2.8
作者：
Abu El-Asrar, Ahmed M.;Struyf, Sofie;Van Damme, Jo
通讯作者：
Van Damme, Jo
影响因子：
4
作者：
Chu, Qing;Zhang, Jingfa;Xu, Guo-Tong
通讯作者：
Xu, Guo-Tong
影响因子：
3.9
作者：
Carmo, A;Cunha-Vaz, JG;Lopes, MC
通讯作者：
Lopes, MC