Respiratory-gated Proton Beam Therapy for Hepatocellular Carcinoma Adjacent to the Gastrointestinal Tract without Fiducial Markers.
Respiratory-gated Proton Beam Therapy for Hepatocellular Carcinoma Adjacent to the Gastrointestinal Tract without Fiducial Markers.
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DOI：
10.3390/cancers10020058
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发表时间：
2018-02-21
期刊：
影响因子：
5.2
通讯作者：
Gabata T
中科院分区：
文献类型：
--
作者：
Mizuhata M;Takamatsu S;Shibata S;Bou S;Sato Y;Kawamura M;Asahi S;Tameshige Y;Maeda Y;Sasaki M;Kumano T;Kobayashi S;Yamamoto K;Tamamura H;Gabata T
质子束疗法(PBT)治疗肝细胞癌的疗效已有报道，但通常需要在肝脏植入基准标记物。我们评估了无基准标记物的呼吸门控PBT治疗位于胃肠道2厘米以内的肝细胞癌的疗效和毒性。从2011年3月至2015年12月，在我们机构对40名患者进行了评估(平均年龄72岁；范围38-87岁)。所有患者都接受了PBT，剂量为60~80个钴的灰当量(CGE)，分20~38次。中位随访期为19.9个月(1.2~72.3个月)。肿瘤平均大小为36.5 mm(11~124 mm)。Kaplan-Meier估计的两年总生存率、无进展生存率和局部肿瘤控制率分别为76%、60%和94%。1名患者(2.5%)发展为3级胃溃疡，1名(2.5%)发展为3级腹水滞留；其余患者均未出现3级毒性反应(国家癌症研究所不良事件通用术语标准VER)。4.0)。这项研究表明，对于位于胃肠道2厘米以内的肝癌，无基准标记的PBT可以实现良好的局部控制，而不会出现严重的胃肠道治疗相关毒性。
The efficacy of proton beam therapy (PBT) for hepatocellular carcinoma (HCC) has been reported, but insertion of fiducial markers in the liver is usually required. We evaluated the efficacy and toxicity of respiratory-gated PBT without fiducial markers for HCC located within 2 cm of the gastrointestinal tract. From March 2011 to December 2015 at our institution, 40 patients were evaluated (median age, 72 years; range, 38–87 years). All patients underwent PBT at a dose of 60 to 80 cobalt gray equivalents (CGE) in 20 to 38 fractions. The median follow-up period was 19.9 months (range, 1.2–72.3 months). The median tumor size was 36.5 mm (range, 11–124 mm). Kaplan–Meier estimates of the 2-year overall survival, progression-free survival, and local tumor control rates were 76%, 60%, and 94%, respectively. One patient (2.5%) developed a grade 3 gastric ulcer and one (2.5%) developed grade 3 ascites retention; none of the remaining patients developed grade >3 toxicities (National Cancer Institute Common Terminology Criteria for Adverse Events ver. 4.0.). This study indicates that PBT without fiducial markers achieves good local control without severe treatment-related toxicity of the gastrointestinal tract for HCC located within 2 cm of the gastrointestinal tract.
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DOI：
10.1016/s0360-3016(01)01649-2
发表时间：
2001-09-01
影响因子：
7
作者：
Balter, JM;Dawson, LA;Ten Haken, R
通讯作者：
Ten Haken, R
影响因子：
6.2
作者：
Nakayama, Hidetsugu;Sugahara, Shinji;Tokuuye, Koichi
通讯作者：
Tokuuye, Koichi
影响因子：
5.7
作者：
Fukuda K;Okumura T;Abei M;Fukumitsu N;Ishige K;Mizumoto M;Hasegawa N;Numajiri H;Ohnishi K;Ishikawa H;Tsuboi K;Sakurai H;Hyodo I
通讯作者：
Hyodo I
影响因子：
3.7
作者：
Takamatsu S;Yamamoto K;Maeda Y;Kawamura M;Shibata S;Sato Y;Terashima K;Shimizu Y;Tameshige Y;Sasaki M;Asahi S;Kondou T;Kobayashi S;Matsui O;Gabata T
通讯作者：
Gabata T
DOI：
10.1016/j.ijrobp.2007.09.056
发表时间：
2008-06-01
影响因子：
7
作者：
Mizumoto, Masashi;Tokuuye, Koichi;Minami, Manabu
通讯作者：
Minami, Manabu