Modular degradable hydrogels based on thiol-reactive oxanorbornadiene linkers.
Modular degradable hydrogels based on thiol-reactive oxanorbornadiene linkers.
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基于硫醇反应性氧杂降冰片二烯连接体的模块化可降解水凝胶。
DOI：
10.1021/jacs.5b02708
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发表时间：
2015-04-22
影响因子：
15
通讯作者：
Finn MG
中科院分区：
文献类型：
--
作者：
Higginson CJ;Kim SY;Peláez-Fernández M;Fernández-Nieves A;Finn MG
氧杂降冰片二烯二羧酸酯（OND）试剂是有效的Michael受体，其加合物通过逆Diels-桤木反应以随OND部分上的取代模式而变化的速率经历断裂。巯基封端的四价PEG和多价OND之间的快速缀合物加成在生理温度和pH下在1分钟内产生自支撑水凝胶。代表性水凝胶制剂的侵蚀发生在几分钟至几周的量级上，具有可预测的和pH无关的速率。这些材料可以通过OND连接体的环氧化而变得不可降解，而不会减缓凝胶化。用等价的OND连接体制备的水凝胶具有相当的物理性质，如通过平衡溶胀行为所确定的，表明类似的内部网络结构。夹带货物的扩散和释放随PEG-OND水凝胶的降解速率和夹带物质的流体动力学半径而变化。这些结果突出了OND连接体在制备可降解网络材料中的实用性，其具有在持续释放中的潜在应用。
Oxanorbornadiene dicarboxylate (OND) reagents are potent Michael acceptors, the adducts of which undergo fragmentation by retro-Diels–Alder reaction at rates that vary with the substitution pattern on the OND moiety. Rapid conjugate addition between thiol-terminated tetravalent PEG and multivalent ONDs yielded self-supporting hydrogels within 1 min at physiological temperature and pH. Erosion of representative hydrogel formulations occurred with predictable and pH-independent rates on the order of minutes to weeks. These materials could be made non-degradable by epoxidation of the OND linkers without slowing gelation. Hydrogels prepared with OND linkers of equal valence had comparable physical properties, as determined by equilibrium swelling behavior, indicating similar internal network structure. Diffusion and release of entrained cargo varied with both the rate of degradation of PEG-OND hydrogels and the hydrodynamic radius of the entrained species. These results highlight the utility of OND linkers in the preparation of degradable network materials with potential applications in sustained release.
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影响因子：
5.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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