Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells.
Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells.
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神经系统中的免疫反应性：神经胶质细胞调节 T 淋巴细胞活化。
DOI：
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发表时间：
1987
影响因子：
2.8
通讯作者：
R. Meyermann
中科院分区：
文献类型：
--
作者：
H. Wekerle;Deming Sun;R. Oropeza;R. Meyermann
脊椎动物中枢神经系统（CNS）传统上被认为是免疫系统的乘客淋巴细胞无法进入的。但事实似乎并非如此：活化的t淋巴细胞可以很容易地穿过内皮血脑屏障（BBB），一些胶质细胞，尤其是星形胶质细胞，似乎被编程为抗原特异性t淋巴细胞最有效和最复杂的伙伴。我们使用髓鞘碱性蛋白（MBP）特异性永久大鼠t淋巴细胞系作为探针来评估中枢神经系统的免疫状态。这些细胞在体外激活后，能够将实验诱导的致死性自身免疫性脑脊髓炎（EAE）转移到正常的同基因受体。活化的t淋巴细胞，而不是静止的t淋巴细胞，不管它们的抗原特异性如何，都可以突破血脑屏障。因此，中枢神经系统的免疫监视似乎是由活化的t淋巴细胞执行的。在穿过血脑屏障后，活化的t细胞通过释放包括干扰素在内的因子与局部胶质细胞相互作用，诱导星形胶质细胞在其膜上合成和表达II类主要组织相容性抗原（Ia决定因子），这对于抗原向t细胞的免疫原性呈递至关重要。事实上，ia诱导的中枢神经系统星形胶质细胞（以及周围神经的雪旺细胞）是有效的抗原呈递细胞，能够强烈上调抗原反应性t淋巴细胞。此外，最近有研究表明，至少有一些星形胶质细胞能够下调免疫细胞。一些，但不是全部，星形胶质细胞能够抑制t细胞的激活。这种抑制可以通过干扰素- γ调节，并且对辐照敏感。抑制是通过细胞间直接接触还是通过可溶性介质（如载脂蛋白E）介导的，目前正在研究中。星形胶质细胞已被发现是最微妙的调节免疫能力的t细胞。最有可能的是，它们主要参与中枢神经系统的生理免疫反应，并且了解胶质细胞在免疫系统和神经系统之间传递调节信号的程度将是诱人的。
The vertebrate central nervous system (CNS) has been traditionally thought to be inaccessible for the passenger lymphocytes of the immune system. This does not seem to be the case: activated T-lymphocytes can readily cross the endothelial blood-brain barrier (BBB) and some glial cells, notably the astrocytes, seem to be programmed to act as most efficient and complex partners for antigen-specific T-lymphocytes. We used myelin basic protein (MBP) specific permanent rat T-lymphocyte lines as probes to assess the immune status of the CNS. These cells, upon activation in vitro, are able to transfer lethal, experimentally induced autoimmune-encephalomyelitis (EAE) to normal syngeneic recipients. Activated T-lymphocytes, but not resting ones, can break through the BBB irrespective of their antigen specificity. Immune surveillance of the CNS thus seems to be executed by activated T-lymphocytes. Having crossed the BBB, the activated T-cells interact with local glial cells by releasing factors, including interferon-gamma, which induced astrocytes to synthesize and express, on their membranes, class II major histocompatibility antigens (Ia determinants), which are critically required for immunogenic presentation of antigens to T-cells. Indeed, Ia-induced astrocytes of the CNS (and the Schwann cells of peripheral nerves) are efficient antigen presenter cells, which are able strongly to up-regulate antigen-reactive T-lymphocytes. In addition, it has recently been shown that at least some astrocytes are able to down-regulate immune cells. Some, but not all, astrocytes are capable of suppressing activation of T-cells. This suppression can be modulated by interferon-gamma, and is sensitive to irradiation. The question of whether suppression is mediated by direct cell-to-cell contact or via soluble mediators (e.g. apolipoprotein E) is under investigation. Astrocytes have been found to be most subtle regulators of immuno-competent T-cells. Most probably they are centrally involved in physiological immune reactivity of the CNS, and it will be tempting to learn how far glial cells are involved in transmitting regulatory signals between the immune and nervous systems.
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小鼠慢性复发实验性自身免疫性脑脊髓炎病变的免疫病理学。
影响因子：
4.3
作者：
Traugott,U;McFarlin,DE;Raine,CS
通讯作者：
Raine,CS
从急性实验性过敏性脑脊髓炎中恢复的 Lewis 大鼠脊髓中的抑制性 T 淋巴细胞。
影响因子：
4.3
作者：
Hickey,WF;Gonatas,NK
通讯作者：
Gonatas,NK
主要组织相容性复合物控制小鼠对髓磷脂碱性蛋白的免疫反应。
DOI：
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发表时间：
1985
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fritz,RB;Skeen,MJ;Chou,CH;Garcia,M;Egorov,IK
通讯作者：
Egorov,IK
DOI：
--
发表时间：
1985-08
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
S. Izumo;C. Linington;H. Wekerle;R. Meyermann
通讯作者：
S. Izumo;C. Linington;H. Wekerle;R. Meyermann
影响因子：
56.9
作者：
GIULIAN, D;LACHMAN, LB
通讯作者：
LACHMAN, LB