The effects of long-term aerobic exercise and energy restriction on protein synthesis.

The effects of long-term aerobic exercise and energy restriction on protein synthesis.
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长期有氧运动和能量限制对蛋白质合成的影响。

DOI:
10.1016/0026-0495(95)90263-5
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发表时间:
1995
期刊:
Metabolism: clinical and experimental
影响因子:
--
通讯作者:
Klein,I
Klein,I
中科院分区:
--
文献类型:
--
作者:
Katzeff,HL;Ojamaa,KM;Klein,I

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长期有氧运动和能量摄入以复杂的方式调节身体成分。为了研究运动和能量限制对肌肉质量的综合影响,我们测量了雌性大鼠在两个能量限制水平下(每日跑步或不跑步)28天后骨骼肌和心肌蛋白质的合成。用~ 3 H-Phe掺入法测定泛流脉冲注射后10分钟的蛋白质合成。两个运动加能量限制组的骨骼肌和心肌质量比他们的食物匹配组更大。心肌、腓肠肌和比目鱼肌蛋白质合成率与其肌肉质量成正比。运动引起的能量不足保存心脏和比目鱼肌质量在更大程度上比腓肠肌质量,而能量限制的影响是相似的,在所有三个肌肉。这些发现表明,能量摄入和运动对肌肉质量和蛋白质合成的调节具有独立的影响。
Long-term aerobic exercise and energy intake regulate body composition in a complex manner. To study the combined effects of exercise and energy restriction on muscle mass, we measured skeletal and cardiac muscle protein synthesis after 28 days of two levels of energy restriction with or without daily running-wheel exercise in female rats. Protein synthesis was measured as3H-Phe incorporation 10 minutes' postbolus of a flooding pulse injection. The two exercise plus energy-restriction groups had greater skeletal muscle and cardiac muscle mass compared with their food-matched groups. Cardiac, gastrocnemius, and soleus muscle protein synthetic rates were proportional to their muscle masses. Exercise-induced energy deficits preserved cardiac and soleus mass to a greater extent than gastrocnemius mass, whereas the effects of energy restriction were similar in all three muscles. These findings suggest that energy intake and exercise have independent effects on the regulation of muscle mass and protein synthesis.
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