FAST DB: a website resource for the study of the expression regulation of human gene products.
FAST DB: a website resource for the study of the expression regulation of human gene products.
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DOI：
10.1093/nar/gki738
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发表时间：
2005
影响因子：
14.9
通讯作者：
Auboeuf, D
中科院分区：
文献类型：
--
作者：
de la Grange, P;Dutertre, M;Martin, N;Auboeuf, D
人类基因通过各种机制产生具有不同外显子含量的不同转录本，从而产生具有不同甚至相反生物活性的多种蛋白质同种异构体。为了理解基因转录活性调节的生物学后果，有必要整合基因产生不同功能产物的能力，特别是因为转录刺激也会影响其靶基因产物的外显子含量。为此，我们开发了一套生物信息学套件FAST DB，它可以轻松准确地定义人类基因产生的所有已知转录本的外显子内容。此外，还开发了一些工具，包括所有基因产物的图形表示，所有基因转录物的序列多比对和计算机程序。FAST DB接口还提供广泛的网站资源链接，用于启动子分析和转录因子结合位点预测，剪接调控序列预测以及5 ‘和3 ’非翻译区分析。FAST数据库旨在促进整合转录和转录后事件的研究，以研究人类基因产物的表达调控。
Human genes use various mechanisms to generate different transcripts having different exon content, which in turn generate multiple protein isoforms having differential and even opposite biological activities. To understand the biological consequences of gene transcriptional activity modulation, it is necessary to integrate the capability of genes to generate distinct functional products, particularly because transcriptional stimuli also affect the exon content of their target gene products. For this purpose, we have developed a bioinformatics suite, FAST DB, which defines easily and accurately the exon content of all known transcripts produced by human genes. In addition, several tools have been developed, including a graphical presentation of all gene products, a sequence multi-alignment of all gene transcripts and an in silico PCR computer program. The FAST DB interface also offers extensive links to website resources for promoter analysis and transcription factor binding site prediction, splicing regulatory sequence prediction, as well as 5′- and 3′-untranslated region analysis. FAST DB has been designed to facilitate studies that integrate transcriptional and post-transcriptional events to investigate the expression regulation of human gene products.
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影响因子：
14.9
作者：
Cartegni, L;Wang, JH;Krainer, AR
通讯作者：
Krainer, AR
DOI：
10.1016/j.bbrc.2004.02.077
发表时间：
2004-04-02
影响因子：
3.1
作者：
Nagai, K;Yamaguchi, T;Osumi, T
通讯作者：
Osumi, T
影响因子：
7
作者：
Beaudoing, E;Gautheret, D
通讯作者：
Gautheret, D
影响因子：
14.9
作者：
Lee, C;Atanelov, L;Xing, Y
通讯作者：
Xing, Y
影响因子：
5.3
作者：
Auboeuf, D;Dowhan, DH;O'Malley, BW
通讯作者：
O'Malley, BW