Impact of changed positive and negative task-related brain activity on word-retrieval in aging.
Impact of changed positive and negative task-related brain activity on word-retrieval in aging.
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DOI：
10.1016/j.neurobiolaging.2010.06.020
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发表时间：
2012-04
影响因子：
4.2
通讯作者：
Crosson B
中科院分区：
文献类型：
--
作者：
Meinzer M;Seeds L;Flaisch T;Harnish S;Cohen ML;McGregor K;Conway T;Benjamin M;Crosson B
以前的功能成像研究比较了老年人和年轻人在非语言任务中的活动模式，发现了两种现象的证据：老年参与者通常在大脑半球中表现出更明显的与任务相关的积极活动，而在颞顶叶和中线大脑区域中表现出不太明显的与任务相关的消极活动。然而，这些现象的综合影响和对单词检索的影响尚未得到评估。我们使用功能性磁共振成像来探索语义和音素言语流畅性任务中与任务相关的积极活动（主动任务>基线）和消极活动（基线>主动任务）。在语义任务中右额叶的积极活动增加，在这两项任务中右半球的消极活动减少，与老年受试者的表现下降有关。在老年参与者中观察到积极和消极活动的变化之间没有实质性的关系，指向两个部分独立但可能共同发生的过程。在老年人的词检索过程中观察到的功能网络效率低下的根本原因需要在未来确定。
Previous functional imaging studies that compared activity patterns in older and younger adults during non-linguistic tasks found evidence for two phenomena: older participants usually show more pronounced task-related positive activity in the brain hemisphere that is not dominant for the task and less pronounced negative task-related activity in temporo-parietal and midline brain regions. The combined effects of these phenomena and the impact on word-retrieval, however, have not yet been assessed. We used functional magnetic resonance imaging to explore task-related positive (active task > baseline) and negative activity (baseline > active task) during semantic and phonemic verbal fluency tasks. Increased right-frontal positive activity during the semantic task and reduced negative activity in the right hemisphere during both tasks was associated with reduced performance in older subjects. No substantial relationship between changes in positive and negative activity was observed in the older participants, pointing towards two partially independent but potentially co-occurring processes. Underlying causes of the observed functional network inefficiency during word-retrieval in older adults need to be determined in the future.
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影响因子：
5.7
作者：
Birn, Rasmus M.;Kenworthy, Lauren;Case, Laura;Caravella, Rachel;Jones, Tyler B.;Bandettin, Peter A.;Martin, Alex
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3.2
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