Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial.
Randomized controlled trial of behavioral treatment for comorbid obesity and depression in women: the Be Active Trial.
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DOI：
10.1038/ijo.2013.25
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发表时间：
2013-11
影响因子：
4.9
通讯作者：
Crawford, S.
中科院分区：
文献类型：
--
作者：
Pagoto, S.;Schneider, K. L.;Whited, M. C.;Oleski, J. L.;Merriam, P.;Appelhans, B.;Ma, Y.;Olendzki, B.;Waring, M. E.;Busch, A. M.;Lemon, S.;Ockene, I.;Crawford, S.
Depression is associated with increased risk for obesity and worse weight loss treatment outcomes. The purpose of the present study was to test the hypothesis that delivering evidence-based behavior therapy for depression prior to a lifestyle weight loss intervention improves both weight loss and depression. In a randomized controlled trial, obese women with major depressive disorder (N=161, mean age=45.9 [SD: 10.8] years) were randomized to brief behavior therapy for depression treatment followed by a lifestyle intervention (BA) or a lifestyle intervention only (LI). Follow-up occurred at 6- and 12-months. Main outcome measures included weight loss and depression symptoms. Intention-to-treat analyses revealed both conditions lost significant weight, but no differences between conditions in weight change at 6-months (BA= −3.0%, SE= − 0.65%; LI=−3.7%, SE = 0.63%; p = 0.48) or 12-months (BA= −2.6%, SE= 0.77%; LI= −3.1%, SE=0.74%; p= 0.72). However, the BA condition evidenced significantly greater improvement in Beck Depression Inventory-II scores relative to the LI condition at both 6-months (BA mean change= −12.5, SD= 0.85; LI mean change= −9.2, SD=0.80, p= 0.005) and 12-months (BA mean change= −-12.6, SD= 0.97; LI mean change= −9.9, SD= 0.93; p = 0.045). Participants who experienced depression remission by 6-months (61.2%) lost greater weight (mean = −4.31%; SE=0.052) than those who did not (39.7%; mean= −2.47%, SE=0.53; p=.001). Adding behavior therapy to a lifestyle intervention results in greater depression remission but does not improve weight loss within one year. Improvement in depression is associated with greater weight loss.
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影响因子：
5.9
作者：
Jacobson, NS;Dobson, KS;Prince, SE
通讯作者：
Prince, SE
影响因子：
4.4
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Clark, MM;Niaura, R;Pera, V
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Pera, V
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5
作者：
Matthews, CE;Freedson, PS;Ockene, IS
通讯作者：
Ockene, IS
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12.8
作者：
Hopko, DR;Lejuez, CW;Eifert, GH
通讯作者：
Eifert, GH
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2.3
作者：
Chuang-Stein, C;Tong, D M
通讯作者：
Tong, D M