Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma.
Co-expression of cancer stem cell markers, SALL4/ALDH1A1, is associated with tumor aggressiveness and poor survival in patients with serous ovarian carcinoma.
复制标题
癌细胞标记物的共表达SALL4/ALDH1A1与浆液性卵巢癌患者的肿瘤侵袭性和生存率差有关。
DOI：
10.1186/s13048-021-00921-x
复制
发表时间：
2022-01-28
影响因子：
4
通讯作者：
Saeednejad Zanjani L
中科院分区：
文献类型：
--
作者：
Sharbatoghli M;Shamshiripour P;Fattahi F;Kalantari E;Habibi Shams Z;Panahi M;Totonchi M;Asadi-Lari Z;Madjd Z;Saeednejad Zanjani L
在浆液性卵巢癌（SOC）中，Spalt-like转录因子4 （SALL4）和醛脱氢酶1家族成员A1 （ALDH1A1）表达细胞具有干细胞样特性，被称为癌症干细胞标志物。通过文献回顾和生物信息学工具观察到SALL4和ALDH1A1之间的关联。因此，本研究旨在通过组织微阵列（TMAs）免疫组化染色，探讨SALL4/ALDH1A1蛋白共表达与SOC患者临床病理参数及其预后价值的关系。此外，将良性肿瘤和正常组织样本与肿瘤组织样本的表达进行比较。SALL4/ALDH1A1的共表达增加与FIGO晚期（P = 0.047）和远处转移（P = 0.028）显著相关。Kaplan-Meier生存分析结果显示，SALL4/ALDH1A1高、低共表达患者的疾病特异性生存（DSS, P = 0.034）或无进展生存（PFS, P = 0.018）差异有统计学意义。此外，在单变量分析中，SALL4/ALDH1A1的高水平共表达是DSS和PFS恶化的重要预测因子。数据还表明，SALL4/ALDH1A1的共表达是影响PFS的独立预后因素。此外，在多变量分析中，SALL4/ALDH1A1的共表达增加了三级与一级SOC患者DSS的预后价值。我们的数据表明，SALL4/ALDH1A1的高共表达与SOC患者的肿瘤侵袭性和更差的DSS或PFS显著相关。因此，在这些病例中，SALL4/ALDH1A1的共表达可能作为癌症进展的潜在预后生物标志物。在线版本包含补充资料，网址为10.1186/s13048-021-00921-x。
Spalt-like transcription factor 4 (SALL4) and aldehyde dehydrogenase1 family member A1 (ALDH1A1) expressing cells have been characterized as possessing stem cell-like properties known as cancer stem cell marker in serous ovarian carcinoma (SOC). The association between SALL4 and ALDH1A1 was observed based on literature review and bioinformatics tools. Therefore, this study aimed to investigate the association between the co-expression of SALL4/ALDH1A1 proteins and clinicopathological parameters and their prognostic value in SOC patients using immunohistochemical staining on tissue microarrays (TMAs). Furthermore, benign tumors and normal tissue samples were compared with the expression of the tumor tissue samples. Increased co-expression of SALL4/ALDH1A1 was found to be significantly associated with the advanced FIGO stage (P = 0.047), and distant metastasis (P = 0.028). The results of Kaplan–Meier survival analysis indicated significant differences between disease- specific survival (DSS; P = 0.034) or progression-free survival (PFS; P = 0.018) and the patients with high and low co-expression of SALL4/ALDH1A1, respectively. Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis. The data also indicated that the co-expression of SALL4/ALDH1A1 was an independent prognostic factor affecting PFS. Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis. Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients. Therefore, co-expression of SALL4/ALDH1A1 may serve as a potential prognostic biomarker of cancer progression in these cases. The online version contains supplementary material available at 10.1186/s13048-021-00921-x.
登录
查看更多内容
影响因子：
3.7
作者：
Lin, Nan-Chin;Hsu, Jui-Ting;Tsai, Kuo-Yang
通讯作者：
Tsai, Kuo-Yang
影响因子：
5.6
作者：
Cao, Dengfeng;Guo, Shuangping;Peng, Yan
通讯作者：
Peng, Yan
影响因子：
2.9
作者：
Gao C;Kong NR;Li A;Tatetu H;Ueno S;Yang Y;He J;Yang J;Ma Y;Kao GS;Tenen DG;Chai L
通讯作者：
Chai L
DOI：
10.1093/bioinformatics/btp101
发表时间：
2009-04-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Bindea G;Mlecnik B;Hackl H;Charoentong P;Tosolini M;Kirilovsky A;Fridman WH;Pagès F;Trajanoski Z;Galon J
通讯作者：
Galon J
DOI：
10.1186/s13046-016-0378-z
发表时间：
2016-06-21
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
He J;Zhou M;Chen X;Yue D;Yang L;Qin G;Zhang Z;Gao Q;Wang D;Zhang C;Huang L;Wang L;Zhang B;Yu J;Zhang Y
通讯作者：
Zhang Y