The innate immune system after ischemic injury: lessons to be learned from the heart and brain.
The innate immune system after ischemic injury: lessons to be learned from the heart and brain.
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DOI：
10.1001/jamaneurol.2013.5026
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发表时间：
2014-02
期刊：
影响因子：
29
通讯作者：
Nahrendorf, Matthias
中科院分区：
文献类型：
--
作者：
Courties, Gabriel;Moskowitz, Michael A.;Nahrendorf, Matthias
先天性免疫细胞在动脉粥样硬化的缺血性并发症中起关键作用。虽然对稳定状态下白细胞的起源和作用有了新的认识，但对脑卒中后骨髓细胞的来源、功能和命运的认识仍然有限。在我们的综述中，我们强调了这一重要领域的开放性问题，同时研究了中风和心肌梗死后免疫反应的潜在相似之处。我们强调需要更好地了解缺血组织，免疫和造血之间的系统性相互作用，因为炎症部位的白细胞转化可能很快，细胞的产生和供应可能成为未来的治疗靶点，以调节血管壁，大脑和心脏的炎症。
Innate immune cells are critically involved in ischemic complications of atherosclerosis. While new insight emerged on the origin and role of leukocytes in steady state, the knowledge about myeloid cell's sources, functions and fate after stroke is limited. In our review, we highlight open questions in this important area while examining potential parallels in the immune response after stroke and myocardial infarction. We stress the need to better understand systemic interactions between ischemic tissue, immunity and hematopoiesis, as turn over of leukocytes in inflammatory sites can be rapid, and cell production and supply may serve as future therapeutic targets to modulate inflammation in the vessel wall, the brain and heart.
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影响因子：
37.8
作者：
Roger VL;Go AS;Lloyd-Jones DM;Benjamin EJ;Berry JD;Borden WB;Bravata DM;Dai S;Ford ES;Fox CS;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Makuc DM;Marcus GM;Marelli A;Matchar DB;Moy CS;Mozaffarian D;Mussolino ME;Nichol G;Paynter NP;Soliman EZ;Sorlie PD;Sotoodehnia N;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
8.3
作者：
Liesz, Arthur;Hagmann, Sebastien;Veltkamp, Roland
通讯作者：
Veltkamp, Roland
影响因子：
6.2
作者：
Seifert, Hilary A.;Hall, Aaron A.;Chapman, Cortney B.;Collier, Lisa A.;Willing, Alison E.;Pennypacker, Keith R.
通讯作者：
Pennypacker, Keith R.
DOI：
10.1126/science.1175202
发表时间：
2009-07-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Swirski FK;Nahrendorf M;Etzrodt M;Wildgruber M;Cortez-Retamozo V;Panizzi P;Figueiredo JL;Kohler RH;Chudnovskiy A;Waterman P;Aikawa E;Mempel TR;Libby P;Weissleder R;Pittet MJ
通讯作者：
Pittet MJ
影响因子：
4.4
作者：
Offner, Halina;Subramanian, Sandhya;Hurn, Patricia D.
通讯作者：
Hurn, Patricia D.