Further characterization of HIV-1 isolates from Ho Chi Minh City, Vietnam.
Further characterization of HIV-1 isolates from Ho Chi Minh City, Vietnam.
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越南胡志明市 HIV-1 分离株的进一步鉴定。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
H. Fleury
中科院分区：
文献类型：
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作者：
T. H. Nguyen;B. Masquelier;V. Pham;T. V. Nguyen;M. Lafon;T. Truong;H. C. Nguyen;F. Sinoussi;H. Fleury
在越南，1990年在胡志明市发现了首例HIV-1感染病例。到1997年12月，已记录到7737例HIV-1感染，母婴传播中心有3153例病例。自从首次描述了来自越南南部静脉吸毒者(IVDU)和妓女的50株HIV-1分离株的亚型以来，作者调查了另外66名来自HCMC的患者；38名IVDU和28名在性病诊所招募的被认为在异性性关系中感染了HIV的受试者。病毒基因组DNA通过聚合酶链式反应和异源双链迁移率分析鉴定流行的HIV-1亚型。在静脉注射吸毒者中，36例感染了HIV-1 E亚型，2例感染了B亚型，25例感染了E亚型，1例感染了C亚型。作者研究了6株E亚型HIV-1野战分离株对比利时生产的非核苷类逆转录酶抑制剂拉米夫定和利托那韦的体外敏感性。分离株对抗逆转录病毒药物的敏感性与HIV-1 B亚型参考毒株非常相似，这表明西方国家用于招募患者进行双重和/或三重治疗的指南也适用于越南患者。
In Vietnam the first case of HIV-1 infection was identified in Ho Chi Minh City (HCMC) in 1990. By December 1997 7737 HIV-1 infections had been recorded with 3153 cases in HCMC. Since first describing the subtypes of 50 HIV-1 isolates from IV drug users (IVDUs) and prostitutes in South Vietnam the authors investigated 66 additional patients from HCMC; 38 IVDUs and 28 subjects recruited in a STD clinic and thought to have been infected with HIV in the course of heterosexual sexual relations. Prevalent HIV-1 subtypes were identified through polymerase chain reaction and heteroduplex mobility assay applied to viral genomic DNA. Of the IVDUs 36 were infected with HIV-1 subtype E and 2 with subtype B. Of the STD patients 25 were infected with HIV-1 subtype E 2 with subtype B and 1 with subtype C. The authors then investigated the in vitro sensitivity of 6 HIV-1 subtype E field isolates to zidovudine dideoxycytidine stavudine lamivudine a non-nucleoside reverse transcriptase inhibitor manufactured in Belgium and ritonavir. The isolates sensitivity to the antiretroviral drugs is very similar to that of HIV-1 subtype B reference strains suggesting that the guidelines used to enroll patients in double and/or triple therapy in Western countries are also valid for patients in Vietnam.
泰国北部早期血清转化者中全长 E 亚型 HIV 1 型 env 序列的多样性。
DOI：
10.1089/aid.1997.13.1439
发表时间：
1997
期刊：
AIDS research and human retroviruses.
影响因子：
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作者：
Yu,XF;Wang,Z;Beyrer,C;Celentano,DD;Khamboonruang,C;Nelson,K
通讯作者：
Nelson,K