Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.
Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.
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DOI：
10.1155/2014/834294
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发表时间：
2014
影响因子：
4.6
通讯作者：
Yu R
中科院分区：
文献类型：
--
作者：
Le NH;Kim CS;Park T;Park JH;Sung MK;Lee DG;Hong SM;Choe SY;Goto T;Kawada T;Yu R
骨骼肌炎症和萎缩与胰岛素抵抗等代谢障碍密切相关。槲皮素是一种天然多酚类黄酮，具有抗炎和抗氧化活性。在这项研究中，我们研究了它对肥胖诱导的小鼠骨骼肌炎症和萎缩的影响。雄性C57 BL/6小鼠喂食常规饮食、高脂饮食（HFD）和添加槲皮素的HFD 9周。槲皮素降低了HFD喂养的肥胖小鼠骨骼肌中炎性细胞因子和巨噬细胞积聚的水平。它还降低了HFD喂养的肥胖小鼠骨骼肌中特定萎缩因子Atrogin-1和MuRF 1的转录和蛋白水平，并防止肌肉质量和肌纤维尺寸减少。在体外，槲皮素显着减少炎症受体的转录水平和激活其信号分子（ERK，p38 MAPK，和NF-κB）在共培养的肌管/巨噬细胞，这是伴随着减少的萎缩因子的表达。总之，这些发现表明槲皮素通过抑制炎症受体及其信号通路来减少肥胖诱导的骨骼肌萎缩。槲皮素可用于预防肥胖引起的肌肉炎症和肌肉减少症。
Skeletal muscle inflammation and atrophy are closely associated with metabolic impairment such as insulin resistance. Quercetin, a natural polyphenol flavonoid, is known to elicit anti-inflammatory and antioxidant activities. In this study, we investigated its effect on obesity-induced skeletal muscle inflammation and atrophy in mice. Male C57BL/6 mice were fed a regular diet, a high-fat diet (HFD), and an HFD supplemented with quercetin for nine weeks. Quercetin reduced levels of inflammatory cytokines and macrophage accumulation in the skeletal muscle of the HFD-fed obese mice. It also reduced transcript and protein levels of the specific atrophic factors, Atrogin-1 and MuRF1, in the skeletal muscle of the HFD-fed obese mice, and protected against the reduction of muscle mass and muscle fiber size. In vitro, quercetin markedly diminished transcript levels of inflammatory receptors and activation of their signaling molecules (ERK, p38 MAPK, and NF-κB) in cocultured myotubes/macrophages, and this was accompanied by reduced expression of the atrophic factors. Together, these findings suggest that quercetin reduces obesity-induced skeletal muscle atrophy by inhibiting inflammatory receptors and their signaling pathway. Quercetin may be useful for preventing obesity-induced muscle inflammation and sarcopenia.
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DOI：
10.1097/mco.0b013e32831cef61
发表时间：
2009-01
影响因子：
3.1
作者：
Durham WJ;Dillon EL;Sheffield-Moore M
通讯作者：
Sheffield-Moore M
影响因子：
6
作者：
Kwon B
通讯作者：
Kwon B
影响因子：
4.9
作者：
Overman, A.;Chuang, C-C;McIntosh, M.
通讯作者：
McIntosh, M.
影响因子：
3.7
作者：
Henagan TM;Lenard NR;Gettys TW;Stewart LK
通讯作者：
Stewart LK
影响因子：
4.8
作者：
Samaan MC
通讯作者：
Samaan MC