An overview of the genomics of metabolic syndrome.
An overview of the genomics of metabolic syndrome.
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DOI：
10.1111/j.1547-5069.2012.01484.x
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Cashion A
中科院分区：
文献类型：
--
作者：
Taylor JY;Kraja AT;de Las Fuentes L;Stanfill AG;Clark A;Cashion A
本文简要介绍了代谢综合征（MetS）的诊断标准和基因组危险因素。本文综述了心血管、肥胖和糖尿病基因组危险因素对代谢综合征发生的影响。MetS发展的基因组风险因素与构成疾病组分的基因组风险因素密切相关。代谢综合征的许多心血管和肾脏基因组风险因素与高血压和血脂异常的发生相似。肥胖可能是一个主触发器，开启了疾病其他成分所必需的基因表达变化。2型糖尿病的基因组学研究表明，许多重叠基因和多态性影响糖尿病和代谢综合征的发展。虽然卫生从业者现在有一些见解的基因组学的风险因素与代谢综合征，代谢综合征的整体认识仍然不足。基于一些讨论的基因组风险因素的临床应用正在开发中，但尚未用于MetS的诊断和治疗。广泛了解基因组对疾病过程的贡献将使临床医生能够更好地利用基因组学来评估和定制患者的管理。
This article provides a brief overview of the diagnostic criteria and genomic risk factors for the components of metabolic syndrome (MetS). Contributions of cardiovascular, obesity, and diabetes genomic risk factors to the development of MetS as reported in the literature have been reviewed. The genomic risk factors for the development of MetS are strongly linked to the genomic risk factors that make up the components of the disease. Many of the cardiovascular and renal genomic risk factors for MetS development are similar to those found in the development of hypertension and dyslipidemia. Obesity may act as a master trigger to turn on the gene expression changes necessary for the other components of the disease. Studies in the genomics of type 2 diabetes show a number of overlapping genes and polymorphisms that influence both the development of diabetes and MetS. Although health practitioners now have some insights into the genomics of risk factors associated with MetS, the overall understanding of MetS remains inadequate. Clinical applications based on some of the discussed genomic risk factors are being developed but are not yet available for the diagnosis and treatment of MetS. A broad knowledge of the genomic contributions to disease processes will enable the clinician to better utilize genomics to assess and tailor management of patients.
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影响因子：
5.6
作者：
Basson J;Simino J;Rao DC
通讯作者：
Rao DC
影响因子：
4.3
作者：
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通讯作者：
Wung, Shu-Fen
影响因子：
5
作者：
Hoffmann, MM;Scharnagl, H;März, W
通讯作者：
März, W
影响因子：
6.9
作者：
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通讯作者：
Fritsche, Andreas
影响因子：
--
作者：
Ioannidis, John P. A.
通讯作者：
Ioannidis, John P. A.