A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
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DOI：
10.1111/all.13232
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发表时间：
2018-01
期刊：
影响因子：
12.4
通讯作者：
Litonjua AA
中科院分区：
文献类型：
--
作者：
Savage JH;Lee-Sarwar KA;Sordillo J;Bunyavanich S;Zhou Y;O'Connor G;Sandel M;Bacharier LB;Zeiger R;Sodergren E;Weinstock GM;Gold DR;Weiss ST;Litonjua AA
肠道微生物组的改变与哮喘的发生具有前瞻性相关性;关于微生物组改变在食物过敏发生中的作用知之甚少。在3-6个月大时收集了参与妊娠期间给予高剂量维生素D的干预性试验的随访阶段的儿童的肠道微生物组样本。在3岁时，评估了对食物（牛奶、鸡蛋、花生、大豆、小麦、核桃）的致敏性。食物过敏定义为看护人报告的3岁之前由医疗保健提供者诊断的对上述食物过敏，并有IgE致敏证据。使用Phyloseq和DESeq 2进行分析;针对多重比较调整P值。225名儿童的完整数据可用;有87例食物致敏和14例食物过敏。食物致敏和食物过敏病例和对照组之间的微生物多样性指标没有差异。在食物致敏受试者中，嗜血杆菌属（log 2倍数变化-2.15，P=.003）、小杆菌属（log 2倍数变化-2.22，P=.009）、多雷氏菌属（log 2倍数变化-1.65，P=.02）和梭菌属（log 2倍数变化-1.47，P=.002）的代表性不足。柠檬酸杆菌属（log 2倍数变化-3.41，P=.03）、颤螺旋菌属（log 2倍数变化-2.80，P=.03）、乳球菌属（log 2倍数变化-3.19，P=.05）和Dorea属（log 2倍数变化-3.00，P=.05）在食物过敏受试者中的代表性不足。细菌定植与食物致敏和过敏之间的时间关联表明微生物组可能在食物过敏的发展中起因果作用。我们的研究结果对预防和治疗食物过敏具有治疗意义。
Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. Intestinal microbiome samples were collected at age 3–6 months in children participating in the follow-up phase of an interventional trial of high-dose vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed. Food allergy was defined as caretaker report of healthcare provider-diagnosed allergy to the above foods prior to age 3 with evidence of IgE sensitization. Analysis was performed using Phyloseq and DESeq2; P-values were adjusted for multiple comparisons. Complete data were available for 225 children; there were 87 cases of food sensitization and 14 cases of food allergy. Microbial diversity measures did not differ between food sensitization and food allergy cases and controls. The genera Haemophilus (log2 fold change −2.15, P=.003), Dialister (log2 fold change −2.22, P=.009), Dorea (log2 fold change −1.65, P=.02), and Clostridium (log2 fold change −1.47, P=.002) were underrepresented among subjects with food sensitization. The genera Citrobacter (log2 fold change −3.41, P=.03), Oscillospira (log2 fold change −2.80, P=.03), Lactococcus (log2 fold change −3.19, P=.05), and Dorea (log2 fold change −3.00, P=.05) were underrepresented among subjects with food allergy. The temporal association between bacterial colonization and food sensitization and allergy suggests that the microbiome may have a causal role in the development of food allergy. Our findings have therapeutic implications for the prevention and treatment of food allergy.
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影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
2.8
作者：
Han, Kyoung Jun;Lee, Na-Kyoung;Paik, Hyun-Dong
通讯作者：
Paik, Hyun-Dong
影响因子：
2.2
作者：
Litonjua AA;Lange NE;Carey VJ;Brown S;Laranjo N;Harshfield BJ;O'Connor GT;Sandel M;Strunk RC;Bacharier LB;Zeiger RS;Schatz M;Hollis BW;Weiss ST
通讯作者：
Weiss ST
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1073/pnas.0804812105
发表时间：
2008-10-28
影响因子：
11.1
作者：
Sokol, Harry;Pigneur, Benedicte;Langella, Philippe
通讯作者：
Langella, Philippe