From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer.

From Nanowarming to Thermoregulation: New Multiscale Applications of Bioheat Transfer.
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DOI:
10.1146/annurev-bioeng-071516-044532
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发表时间:
2018-06-04
影响因子:
9.7
通讯作者:
Diller KR
Diller KR
中科院分区:
工程技术1区
文献类型:
--
作者:
Bischof JC;Diller KR

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Over the past decade the field of bioheat transfer has grown dramatically in part due to new medical applications. Here we review a part of this growth stemming from nanoparticle heating to whole body thermoregulation. This includes foundational multiscale engineering developments and physiological expertise that support the whole field of bioheat transfer. Many of these new technologies must be considered as revolutionary rather than just evolutionary. The gateway to these advances has occurred via a combination of new engineering materials and methods that may be adapted for heat transfer applications in conjunction with remarkable mechanistic insights into the function of living systems spanning from the molecular and cellular to physiological levels. Thus, the length scales across which these bioheat transfer phenomena occur span at least six orders of magnitude. This review presents a concise summary of the current state of understanding of the engineering and physiological principles that govern these bioheat transfer processes over nm to cm scales and beyond. We then show the dramatic opportunities for translation and impact in prophylactic, preservative, diagnostic, and therapeutic applications based on nanoparticle heating and whole body thermoregulation.
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