Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges.
Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges.
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DOI：
10.1186/s40169-018-0192-7
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发表时间：
2018-05-31
影响因子：
10.6
通讯作者：
Trau M
中科院分区：
文献类型：
--
作者：
Lane RE;Korbie D;Hill MM;Trau M
细胞外囊泡（EV）是含有核酸和蛋白质货物的小的脂质结合颗粒，其在各种正常和病理条件下从细胞中分泌。近年来，EV已经引起了大量的研究兴趣，因为它们作为各种疾病（包括许多类型的癌症）的循环生物标志物的潜在用途。以下综述将讨论目前对EV的形式和功能的理解，它们在癌症发病机制中的特定作用以及它们在非侵入性疾病诊断和/或监测中的潜力。本次审查还将强调这一领域的几个关键问题，包括实施稳健和可重复的样品处理方案的重要性，以及从复杂的生物背景中提取EV特异性生物标志物信号的挑战。
Extracellular vesicles (EVs) are small, lipid-bound particles containing nucleic acid and protein cargo which are excreted from cells under a variety of normal and pathological conditions. EVs have garnered substantial research interest in recent years, due to their potential utility as circulating biomarkers for a variety of diseases, including numerous types of cancer. The following review will discuss the current understanding of the form and function of EVs, their specific role in cancer pathogenesis and their potential for non-invasive disease diagnosis and/or monitoring. This review will also highlight several key issues for this field, including the importance of implementing robust and reproducible sample handling protocols, and the challenge of extracting an EV-specific biomarker signal from a complex biological background.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
3.8
作者：
Goto T;Fujiya M;Konishi H;Sasajima J;Fujibayashi S;Hayashi A;Utsumi T;Sato H;Iwama T;Ijiri M;Sakatani A;Tanaka K;Nomura Y;Ueno N;Kashima S;Moriichi K;Mizukami Y;Kohgo Y;Okumura T
通讯作者：
Okumura T
影响因子：
16.6
作者：
Desrochers LM;Bordeleau F;Reinhart-King CA;Cerione RA;Antonyak MA
通讯作者：
Antonyak MA
影响因子：
3.9
作者：
Anderson, Will;Lane, Rebecca;Trau, Matt
通讯作者：
Trau, Matt
影响因子：
4.4
作者：
Clayton, Aled;Al-Taei, Saly;Tabi, Zsuzsanna
通讯作者：
Tabi, Zsuzsanna