Systemic immune effects of anesthetics and their intracellular targets in tumors.
Systemic immune effects of anesthetics and their intracellular targets in tumors.
复制标题
麻醉药及其细胞内靶标对肿瘤的系统免疫作用
DOI：
10.3389/fmed.2022.810189
复制
发表时间：
2022
影响因子：
3.9
通讯作者：
Li, Chong
中科院分区：
文献类型：
--
作者：
Luan, Ting;Li, Yi;Sun, Lihui;Xu, Siqi;Wang, Haifeng;Wang, Jiansong;Li, Chong
关键词：
根据世界卫生组织（世卫组织）公布的结果，非传染性疾病在目前世界十大死亡原因中占据了四个。癌症是引发并发症和死亡的重要因素之一；超过80%的癌症患者需要手术或姑息治疗。在这种情况下，麻醉治疗是必不可少的。由于癌症是一种异质性疾病，各种类型的干预可以激活癌基因或突变肿瘤抑制基因。越来越多的研究者认为麻醉药对肿瘤的长期复发和转移有一定的作用，但究竟是促进还是抑制癌症的进展仍存在争议。在此基础上进行了一系列回顾性或前瞻性随机临床试验，但似乎很难在5年或更长时间内得出结论。本文重点介绍了麻醉药物对免疫功能和肿瘤的影响，并综述了其对肿瘤细胞的最新靶点，以期为优化麻醉药物的选择、探索治疗靶点、改善肿瘤患者的预后提供理论依据。
According to the result released by the World Health Organization (WHO), non-communicable diseases have occupied four of the top 10 current causes for death in the world. Cancer is one of the significant factors that trigger complications and deaths; more than 80% cancer patients require surgical or palliative treatment. In this case, anesthetic treatment is indispensable. Since cancer is a heterogeneous disease, various types of interventions can activate oncogenes or mutate tumor suppressor genes. More and more researchers believe that anesthetics have a certain effect on the long-term recurrence and metastasis of tumors, but it is still controversial whether they promote or inhibit the progression of cancer. On this basis, a series of retrospective or prospective randomized clinical trials have been conducted, but it seems to be difficult to reach a conclusion within 5 years or longer. This article focuses on the effects of anesthetic drugs on immune function and cancer and reviews their latest targets on the tumor cells, in order to provide a theoretical basis for optimizing the selection of anesthetic drugs, exploring therapeutic targets, and improving the prognosis of cancer patients.
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DOI：
10.4103/0970-9185.129996
发表时间：
2014-04
期刊：
Journal of anaesthesiology, clinical pharmacology
影响因子：
--
作者：
Das J;Kumar S;Khanna S;Mehta Y
通讯作者：
Mehta Y
影响因子：
5.6
作者：
Brejchova J;Holan V;Svoboda P
通讯作者：
Svoboda P
肿瘤抑制因子κ阿片受体的下调预示着肝细胞癌患者的不良预后
影响因子：
3.8
作者：
Chen D;Chen Y;Yan Y;Pan J;Xing W;Li Q;Zeng W
通讯作者：
Zeng W
影响因子：
--
作者：
Chen, Xiangyuan;Wu, Qichao;Miao, Changhong
通讯作者：
Miao, Changhong
DOI：
10.1111/1440-1681.13167
发表时间：
2019-09-17
影响因子：
2.9
作者：
Chen, Liufang;Wan, Yingchun;Li, Tao
通讯作者：
Li, Tao