Mental health in the UK Biobank: A roadmap to self-report measures and neuroimaging correlates.
Mental health in the UK Biobank: A roadmap to self-report measures and neuroimaging correlates.
复制标题
DOI：
10.1002/hbm.25690
复制
发表时间：
2022-02-01
影响因子：
4.8
通讯作者：
Bijsterbosch JD
中科院分区：
文献类型：
--
作者：
Dutt RK;Hannon K;Easley TO;Griffis JC;Zhang W;Bijsterbosch JD
英国生物库(UKB)由于其前所未有的样本量和广泛的表型、成像和生物学测量，是研究人群心理健康的脑生物标记物的一个非常有前途的数据集。在这项研究中，我们的目标是为UKB精神健康的神经成像研究提供一个共同的基础，重点是焦虑和抑郁。我们比较了UKB自我报告测量，并揭示了扫描获取和单独在线获取一些心理健康测量之间的重要时序效应。为了克服这些时间效应，我们引入并验证了最近抑郁症状(RDS-4)评分，这是我们在UKB中推荐用于状态依赖和纵向研究的评分。我们进一步测试了脑成像衍生表型(IDPs)和心理健康之间的单变量和多变量关联。我们的结果显示，国内流离失所者和心理健康之间存在显著的多变量关系，这一关系是可复制的。相反，对个别境内流离失所者的影响很小。国内流离失所者的重测信度在衡量大脑结构方面比衡量大脑功能方面更强。综上所述，这些结果为UKB未来对精神健康的脑生物标志物的研究提供了基准和指导方针。在这项研究中，我们的目标是为英国生物库关于精神健康的神经成像研究提供一个共同的基础，重点是焦虑和抑郁。我们介绍并验证了最近抑郁症状(RDS-4)评分，这是我们在英国生物库中推荐用于状态依赖和纵向研究的评分。我们的成像结果显示，成像衍生的表型和心理健康之间存在显著的多变量关系，这是可复制的。
The UK Biobank (UKB) is a highly promising dataset for brain biomarker research into population mental health due to its unprecedented sample size and extensive phenotypic, imaging, and biological measurements. In this study, we aimed to provide a shared foundation for UKB neuroimaging research into mental health with a focus on anxiety and depression. We compared UKB self‐report measures and revealed important timing effects between scan acquisition and separate online acquisition of some mental health measures. To overcome these timing effects, we introduced and validated the Recent Depressive Symptoms (RDS‐4) score which we recommend for state‐dependent and longitudinal research in the UKB. We furthermore tested univariate and multivariate associations between brain imaging‐derived phenotypes (IDPs) and mental health. Our results showed a significant multivariate relationship between IDPs and mental health, which was replicable. Conversely, effect sizes for individual IDPs were small. Test–retest reliability of IDPs was stronger for measures of brain structure than for measures of brain function. Taken together, these results provide benchmarks and guidelines for future UKB research into brain biomarkers of mental health. In this study, we aimed to provide a shared foundation for UK Biobank neuroimaging research into mental health with a focus on anxiety and depression. We introduced and validated the Recent Depressive Symptoms (RDS‐4) score which we recommend for state‐dependent and longitudinal research in the UK Biobank. Our imaging results showed a significant multivariate relationship between imaging‐derived phenotypes and mental health, which was replicable.
登录
查看更多内容
影响因子：
64.8
作者：
Elliott LT;Sharp K;Alfaro-Almagro F;Shi S;Miller KL;Douaud G;Marchini J;Smith SM
通讯作者：
Smith SM
寿命焦虑反映在人类杏仁核皮质连接上
影响因子：
4.8
作者：
He, Ye;Xu, Ting;Zhang, Wei;Zuo, Xi-Nian
通讯作者：
Zuo, Xi-Nian
影响因子：
82.9
作者：
Drysdale AT;Grosenick L;Downar J;Dunlop K;Mansouri F;Meng Y;Fetcho RN;Zebley B;Oathes DJ;Etkin A;Schatzberg AF;Sudheimer K;Keller J;Mayberg HS;Gunning FM;Alexopoulos GS;Fox MD;Pascual-Leone A;Voss HU;Casey BJ;Dubin MJ;Liston C
通讯作者：
Liston C
影响因子：
3.6
作者：
Cannon, Dale S.;Tiffany, Stephen T.;Leppert, Mark F.
通讯作者：
Leppert, Mark F.
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
通讯作者：
Weinberger, DR