Allocentric Spatial Learning by Hippocampectomised Rats: A Further Test of the “Spatial Mapping” and “Working Memory” Theories of Hippocampal Function
Allocentric Spatial Learning by Hippocampectomised Rats: A Further Test of the “Spatial Mapping” and “Working Memory” Theories of Hippocampal Function
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海马切除大鼠的异中心空间学习：海马功能“空间映射”和“工作记忆”理论的进一步检验
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
J. Rawlins
中科院分区：
文献类型：
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作者：
R. Morris;J. Hagan;J. Rawlins
本文报道了一系列的三个实验，以测试海马体功能的“空间映射”和“工作记忆”理论。实验设计采用空间和非空间学习，将水逃逸任务的参考记忆和工作记忆过程分离。在实验1（参考记忆）中，海马（HC）或皮质（CC）损伤的大鼠和未手术的（UNOP）大鼠学会了游泳到一个坚硬的可见的逃生平台，同时避免接触漂浮的平台。在非空间任务中，每个平台在连续的试验中占据池中8个可能位置中的任何一个，但外观不同。在空间任务中，平台具有相同的外观，但安全平台总是占据一个固定的位置。HC大鼠表现出高度特异性的空间学习障碍，但在训练结束时确实学会了始终保持高于机会的表现。在实验2（工作记忆）中，新组的大鼠接受了类似的空间和非空间任务的训练，但根据其视觉外观或空间位置，每天随机更换指定正确的平台。尽管进行了大量的训练，但没有动物学会非空间任务。在空间版本上的表现出乎意料地显示出CC组和HC组相对于UNOP组的损伤。然而，hc的表现再次高于偶然水平，并在训练结束时表现出快速的（I-trial）空间学习。实验3采用地点导航匹配-样本任务进一步考察空间工作记忆。每天，在4个可能的地点中的任何一个隐藏一个水下平台，并给老鼠两次尝试寻找它。试验2中UNOP和CC大鼠比试验1中更快地找到平台，即使间隔时间长达30min。HC大鼠在试验2中的速度并不比试验1快。我们得出结论，海马体损伤(1)严重但部分损害空间参考记忆，而非视觉参考记忆；(2)在不同的工作记忆任务中引起不同的模式损害。这一结果对空间映射理论和工作记忆理论都是一个挑战。
This paper reports a series of three experiments that tested the “spatial-mapping” and “working-memory” theories of hippocampal function. The experimental designs incorporate separate reference- and working-memory procedures of a water-escape task, using both spatial and non-spatial learning. In Experiment 1 (Reference memory), rats with hippocampal (HC) or cortical (CC) lesions and unoperated (UNOP) rats learned to swim to a rigid visible escape platform while avoiding contact with a floating one. In the nonspatial task, the platforms each occupied any of 8 possible positions in the pool over successive trials but differed in appearance. In the spatial task, the platforms were of identical appearance but the safe one always occupied a single fixed location. The HC rats showed a highly specific spatial learning impairment but did learn to perform consistently above chance towards the end of training. In Experiment 2 (working memory), new groups of rats were trained on similar spatial and nonspatial tasks, but the platform designated correct-in terms of its visual appearance or its spatial location-was randomly changed each day. No animal learned the nonspatial task despite extensive training. Performance on the spatial version unexpectedly revealed an impairment in the CC as well as the HC group relative to the UNOP rats. However, the HCs again performed at above chance levels and demonstrated rapid (I-trial) spatial learning towards the end training. Experiment 3 used a place navigation matching-to-sample task examine spatial working memory further. Each day, an underwater platform was hidden at any of 4 possible locations, and the rats were given 2 trials to search for it. Both UNOP and CC rats located the platform faster on Trial 2 than on Trial 1, even when the inter-trial interval was long as 30min. HC rats were no faster on Trial 2 than on Trial 1. We conclude that hippocampal lesions (1) severely but partially impair spatial but not visual reference memory and (2) give rise to different patterns impairment in different working-mermory tasks. The results are a challenge to both the spatial-mapping and working-memory theories.
影响因子：
1.9
作者：
Zola-Morgan,S;Squire,LR
通讯作者：
Squire,LR