Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody.
Adult-onset drug-refractory seizure disorder associated with anti-voltage-gated potassium-channel antibody.
复制标题
DOI：
10.1111/j.1528-1167.2009.02287.x
复制
发表时间：
2010-03
期刊：
影响因子：
5.6
通讯作者：
Geschwind MD
中科院分区：
文献类型：
--
作者：
Barajas RF;Collins DE;Cha S;Geschwind MD
Voltage gated potassium channels are widely expressed throughout the entire nervous system. These channels play a critical role in establishing the resting membrane potential and generation of neuronal action potentials. There is mounting evidence that auto-antibodies reactive to neuronal cell surface antigens, such as voltage-gated potassium channels, play a pathogenic role in a wide spectrum of central and peripheral nervous system disorders. We report a case of new onset drug refractory seizure disorder associated with the presence of high levels of serum anti voltage-gated potassium channel antibodies that responded only to immunotherapy. As demonstrated by this case report, anti voltage-gated potassium channel antibody associated drug refractory seizure disorder, while rare, should be considered in patients with unexplained adult-onset seizure activity. Once the diagnosis has been established the initiation of immunotherapy should be undertaken without delay.
登录
查看更多内容
影响因子：
9.9
作者：
Graus F;Saiz A;Lai M;Bruna J;López F;Sabater L;Blanco Y;Rey MJ;Ribalta T;Dalmau J
通讯作者：
Dalmau J
影响因子：
9.9
作者：
McKnight, K;Jiang, Y;Lang, B
通讯作者：
Lang, B
影响因子：
14.5
作者：
Hart, Ian K.;Maddison, Paul;Mills, Kerry R.
通讯作者：
Mills, Kerry R.
影响因子：
2.2
作者：
Majoie, H. J. Marian;de Baets, Mark;Vincent, Angela
通讯作者：
Vincent, Angela
影响因子：
2.8
作者：
Urbach, Horst;Soeder, Bettina M.;Bien, Christian G.
通讯作者：
Bien, Christian G.