Small Regulatory RNA and Legionella pneumophila.
Small Regulatory RNA and Legionella pneumophila.
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DOI：
10.3389/fmicb.2011.00098
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发表时间：
2011
影响因子：
5.2
通讯作者：
Shuman HA
中科院分区：
文献类型：
--
作者：
Faucher SP;Shuman HA
嗜肺军团菌是一种革兰氏阴性细菌，几乎在任何水性环境中都普遍存在。它是军团病的病原体，军团病是一种急性肺炎，经常被低估。在哺乳动物中，L.嗜肺菌在修饰的空泡内的巨噬细胞内复制。许多蛋白质调节剂已被确定为控制与毒力相关的特性，包括RpoS，LetA/LetS和PmrA/PmrB。在过去的几年中，小调控RNA（sRNAs）调控毒力因子的重要性已越来越受到重视。在L中也是如此。其中三种sRNA（RsmY、RsmZ和6S RNA）最近被证明是毒力调节的重要决定因素，并且鉴定了79种活跃转录的sRNA。在这篇综述中，我们描述了目前的知识，sRNAs及其调控特性，以及如何这涉及到已知的调控系统的L。嗜肺菌我们还提供了一个模型，作为一个框架，了解调控的毒力相关特性的L。嗜肺菌
Legionella pneumophila is a gram-negative bacterial species that is ubiquitous in almost any aqueous environment. It is the agent of Legionnaires’ disease, an acute and often under-reported form of pneumonia. In mammals, L. pneumophila replicates inside macrophages within a modified vacuole. Many protein regulators have been identified that control virulence-related properties, including RpoS, LetA/LetS, and PmrA/PmrB. In the past few years, the importance of regulation of virulence factors by small regulatory RNA (sRNAs) has been increasingly appreciated. This is also the case in L. pneumophila where three sRNAs (RsmY, RsmZ, and 6S RNA) were recently shown to be important determinants of virulence regulation and 79 actively transcribed sRNAs were identified. In this review we describe current knowledge about sRNAs and their regulatory properties and how this relates to the known regulatory systems of L. pneumophila. We also provide a model for sRNA-mediated control of gene expression that serves as a framework for understanding the regulation of virulence-related properties of L. pneumophila.
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DOI：
10.1038/newbio229147a0
发表时间：
1971-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
BROWNLEE, GG
通讯作者：
BROWNLEE, GG
影响因子：
3.6
作者：
Bardill, JP;Miller, JL;Vogel, JP
通讯作者：
Vogel, JP
影响因子：
3.7
作者：
Ansong C;Yoon H;Porwollik S;Mottaz-Brewer H;Petritis BO;Jaitly N;Adkins JN;McClelland M;Heffron F;Smith RD
通讯作者：
Smith RD
影响因子：
10.5
作者：
Boisset, Sandrine;Geissmann, Thomas;Romby, Pascale
通讯作者：
Romby, Pascale
影响因子：
3.2
作者：
Charpentier, Xavier;Faucher, Sebastien P.;Shuman, Howard A.
通讯作者：
Shuman, Howard A.